Protein Alignment TppII and S1P

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: XP_061517038.1
• Gene: S1P / 1280482
• VectorBaseID: AGAMI1_008082
• Length: 1401
• Species: Anopheles gambiae
• Alignment Length: 1149
• Identity: 227/1149 - (19%)
• Similarity: 372/1149 - (32%)
• Gaps: 444/1149 - (38%)

  Fly   320 RIGEYSRTHETRNVDDFLSISVNVHDEGNVLEVVGMSSPHGTHVSSIASGNHSSRDVDGVAPNAK 384
            ||.|.:.....:.:||.:|                    |||.|:.|.:   ||::..|.||:|:
Mosquito   358 RIKERTNWTNEKTLDDGVS--------------------HGTFVAGIIA---SSKECFGFAPDAE 399

  Fly   385 IVSMTIGDGRLGSMETG--TALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEV 447
            :....:......|..:.  .|...|:.|         :|:|:|:|.| ..::.:...:.:::...
Mosquito   400 LHIFRVFTNNQVSYTSWFLDAFNYAILK---------KINVLNLSIG-GPDFLDQPFVDKVLELS 454

  Fly   448 VNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSR 512
            .|:  |:.|::.||.||...|:..|.|  |..:||||.        .:||      .|:..::||
Mosquito   455 ANR--VIMVSAIGNDGPLYGTLNNPGD--QMDVIGVGG--------MDYA------DNIAKFSSR 501

  Fly   513 DPCIDGGQGVTVC-APGGAIASVPQFTMSKSQL-----------MNGTSMAAPHVAGAVALLISG 565
                    |:|.. .|.|.....|......||:           ::|||:|:|.|||||.|:.||
Mosquito   502 --------GMTTWELPYGYGRLKPDIVTYGSQVKGSNLNGGCKSLSGTSVASPMVAGAVTLIASG 558

  Fly   566 -LKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQ-----------SK 618
             |.:..::.:|.|:|:|:...|.:|...:.|.||||.||:.::.:.|..:|.           ::
Mosquito   559 VLDRPGVDLNPASMKQALIEGAERLADNNMFEQGHGKLNILRSMKALAAYRPRVTLSPAYLDFTE 623

  Fly   619 DNMLRF----------------------------------------------------------- 624
            |.|..:
Mosquito   624 DYMWPYTTQSLYYSAMPVIANVTILNGMGVFGRVINRPTWHPYSNEHGELLNVSISYSEQLWPWS 688

  Fly   625 ---SVRVG-NNADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKD-KFNFNVRLNLIASQP-- 682
               :|.:| |.|.:|.   :|:.:..|...|...|  ..:.|.:|:: ..:|.:::.:|...|
Mosquito   689 GWMAVHIGVNEAGRGF---EGIAQGHITLTVQSPP--QGENEREPRNGTVSFAIKVRIIPQPPRQ 748

  Fly   683 ----WVQCGAFLDLSY-----GTRSIAVRVDPTGLQPG-VHSAVIRAYDTDCVQKGSLFEI---P 734
                |.|   :..|.|     ...::.::.||...:.. ||:.....| |.....|...|:   |
Mosquito   749 KRILWDQ---YHSLRYPPGYLPRDNLKIKSDPLDWRADHVHTNFKDMY-THLRNAGYYVEVLGAP 809

  Fly   735 VTVVQPHVLESDQNTPVFEPASSKG-----DNSVEFQPNTIQ--RDFILVPER-------ATWAE 785
            .|...               ||..|     |...||.|..:.  |:.:|  ||       |.|..
Mosquito   810 YTCFN---------------ASHYGTLLVVDPEEEFFPAEVAKLREDVL--ERQLSVIVFADWYN 857

  Fly   786 L----RMRITDPNRGE----DIGKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSG- 841
            .    |::..|.|..:    |.|.                      .:|.:.|:.:..|.:..|
Mosquito   858 TSVMRRIKFYDENTRQWWMPDTGG----------------------ANVPALNDLLRGFGIALGD 900

  Fly   842 RILELCIAKYWSNYGQSHLKYSLRFRGVEAHNPNAYVMHAGRGIHKLEIEAL-----VAEDVQPQ 901
            |:.:    .|:..  :.|..|       .|...|......|.|...:|.:.|     :.:..:|:
Mosquito   901 RVAD----GYFDM--RDHRMY-------YASGANIVRFPVGEGTILVERDLLDEGLAITQPDEPR 952

  Fly   902 LQLKNAEVVL------KPTEAKISPLS---------ATRDVIP-----DGRQVYQNLLAFNLNVA 946
            .:::....:|      :...|::.|.:         |..|.:|     ||.::.::.:.....:.
Mosquito   953 SKVRTRTAILGMLQTDRRVYARLQPATPNPEGAPPLAPPDELPEEWEEDGGKIDRDAIINKRILL 1017

  Fly   947 KAA------DVSIYAPIFNDLLYEAEFESQMWM-----------------------LFDANKA-- 980
            .||      ||.....:.||   ..||.....|                       |.:..||
Mosquito  1018 SAAVGGAGGDVEEDEDVPND---GGEFNRDDAMNRVDAGEEPLPEDDRDGDDLGQLLRERTKAVK 1079

  Fly   981 --------------------LVATGDAHSHTSFTKLDKG---------EYTIRLQVRHEKRDL-- 1014
                                :...||::...| |.|:|.         |||:...|....|||
Mosquito  1080 QHNSTTARTGGRPELLAGGRIALYGDSNCLDS-THLEKPCFWLLDSLLEYTMTAHVTSLLRDLNV 1143

  Fly  1015 ---LEKISEANLVASFKLTSPLTLDFYENYNQCIVG----GRKYVSSPLRLSTRVLYIAPIT--- 1069
               :|:|.|     :.||...:..:....|::.:|.    |.|   .|:.:..|:.:..|:|
Mosquito  1144 SRQVEQIEE-----NVKLPQRMPNNNLHLYSKVLVAHTTTGEK---RPIPVCQRLEWEYPVTLNM 1200

  Fly  1070 -----------------------------QERLTKANLPAQCAWLSGN-LVFPQDEVGRRVAQHP 1104
                                         |:|..|...|.....|.|| ||:  ...|||:
Mosquito  1201 SSLSFGTGPNDHLLVQEQQQQQQQQLLVVQQRQLKQGPPQPIMPLVGNELVY--SSRGRRL---- 1259

  Fly  1105 FTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQ 1169
                          .....|::|.|          ||. :|..|......|....|
Mosquito  1260 --------------ESQKGGNAALG----------AND-EPDVPGWRNKKTDKIPP--------- 1290

  Fly  1170 NDPPVDSSG-SPASPKKGKANA----------------DDYAES 1196
            |.||...:| |.|||..|...|                |.||||
Mosquito  1291 NAPPNGFNGPSGASPTAGTPMAVGVKIIPLAGGSTEDVDYYAES 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	72/283 (25%)
		TPPII	892..1077	CDD:463636	51/310 (16%)
		TPPII_N	1144..1257	CDD:403697	19/70 (27%)
S1P	XP_061517038.1	None