Protein Alignment TppII and Fur2

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: XP_061499326.1
• Gene: Fur2 / 1273048
• VectorBaseID: AGAMI1_010899
• Length: 1513
• Species: Anopheles gambiae
• Alignment Length: 700
• Identity: 139/700 - (19%)
• Similarity: 222/700 - (31%)
• Gaps: 257/700 - (36%)

  Fly    75 TNKEQSDKSAESRMATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGV--DPR 137
            :::.|..:|..||...|   .|...|..:..|...::             |.:|:...||  .|.
Mosquito    16 SHRRQQQQSVHSRAQPS---SSMAGGRWMQVALVALV-------------VAVALHHHGVGASPN 64

  Fly   138 ATGLETLCDGKTVKVIER--YDCSGCGDVDMKKKVTPDE-NGNIKGLSGNSLKLS---------- 189
            ||......:|   |:.||  |:.|...|:     :|||| |..:.......|.|:
Mosquito    65 ATVANGSVNG---KLSERHSYNASASDDL-----ITPDEINAGLLEYFAGPLPLAAMEAAKPKRA 121

  Fly   190 ---PELMALNTDPEKAV--------------RVGLKSFSDLLPSK---------VRNNIVAQAKL 228
               |..:.:|   |.||              :.|..:...:.|.|         ||...|.:::.
Mosquito   122 NARPAAIYMN---EFAVYIPRGADVADSIAHKYGFSNMGQIGPLKGYYLFHHNHVRKRSVDRSEA 183

  Fly   229 KH----------W-----DKPH-KTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEM 277
            .|          |     :||. |...:...:..|.|    ||..|                  :
Mosquito   184 HHNALNTEPEVRWVQQQHEKPRFKRDYSTFDQDFVRF----PGFRS------------------L 226

  Fly   278 LNSYEKVYGDIKTSYDCILFP-----------TADG-------------WL-------TIVDTTE 311
            ::.....|.|..|..   :||           :|:|             |.       .:|...:
Mosquito   227 VSGTRMAYRDTSTHN---IFPDPLFKEQWYLVSANGGAKDGPDMNVGPAWQKGYTGKGVVVSILD 288

  Fly   312 QGDLDQALRIGEYSRTHE--TRNVDDFLSISVNVHDEGNVLEVVGMSSPHGT----HVSSIASGN 370
            .|          ..|.|.  ..|.|...|..:|.:|...:....| .:.|||    .|:::|...
Mosquito   289 DG----------IQRNHPDLALNYDPAASYDINGNDSDPMPRDNG-DNKHGTRCAGEVAAVAFNQ 342

  Fly   371 HSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWS 435
            :..   .|||.||.|..:.:.||      |....|.|  |.:.|..|  .||:.:.|:|...:.|
Mosquito   343 YCG---VGVAYNASIGGVRMLDG------TVNDAVEA--KALGLYPD--HIDIYSASWGPEDDGS 394

  Fly   436 -----------------NSGRIGELMNEVVNKYGVVWVASAGNHG--PALCTV-GTPPDISQPSL 480
                             .|||.|:         |.:::.::||.|  ...|.. |....|...|:
Mosquito   395 TVDGPGPLARRAFIFGVTSGRQGK---------GSIFIWASGNGGRYTDSCNCDGYTNSIFTLSI 450

  Fly   481 IGV--GAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSKSQ 543
            ...  |.|....:.|....:       ..|::|..|..|  :.|......|::......|:..:
Mosquito   451 SSATQGGYKPWYLEECSSTL-------ATTYSSGTPGHD--KSVATVDMDGSLRPDRICTVEHT- 505

  Fly   544 LMNGTSMAAPHVAGAVALLIS---GLKQQNIEY--------SPY---------SIKRAISVTATK 588
               |||.:||..||..||.:.   .|..::::|        .|.         .:||.:|   .|
Mosquito   506 ---GTSASAPLAAGIAALALEANPALTWRDMQYLVVLTSRSDPLEKEPGWILNGVKRKVS---HK 564

  Fly   589 LGYVDPFAQGHGLLNVEKAF-----------EHLTEHRQ-SKDNMLRFSV 626
            .||        ||::.....           :|:.:.|: ::|..:..||
Mosquito   565 FGY--------GLMDAGAMVSLAEQWTTVPSQHICKSREINEDRPIEVSV 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	122/623 (20%)
		TPPII	892..1077	CDD:463636
		TPPII_N	1144..1257	CDD:403697
Fur2	XP_061499326.1	None