DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and tpp2

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:XP_005168067.1 Gene:tpp2 / 100331669 ZFINID:ZDB-GENE-121214-290 Length:1263 Species:Danio rerio


Alignment Length:1399 Identity:499/1399 - (35%)
Similarity:750/1399 - (53%) Gaps:181/1399 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 MATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGLETLCDGKTVKV 152
            |:.....|.||...|:||.|||..:||.||||||||.|.|||.|:||||.|.|::...|||. |:
Zfish     1 MSAHSAEEPFPFHGLLPKKETGAASFLTKYPEYDGRGVLIAILDTGVDPGAPGMQITTDGKP-KI 64

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGLKSFSDLLPSK 217
            ::..|.:|.|||:|...|...| |::.||:|.:||:.    |...:|.....:|:|:..|..|..
Zfish    65 VDIIDTTGSGDVNMSTVVEVKE-GSVSGLTGRTLKIP----AAWVNPSGKYHIGVKNGYDFFPKA 124

  Fly   218 VRNNIVAQAKLKHWDKPHKTATANASRKIVEFES--QNPGEASKLPWDKKILKENLDFELEMLNS 280
            ::..|..:.|.|.||..|:.|.|.|||:..||:.  .||.:..||.      ||.|...:|:|..
Zfish   125 LKERIQKERKEKLWDPTHRAALAEASRRTEEFDQTHTNPSQMEKLQ------KEELQCHVELLGM 183

  Fly   281 YEKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHE--TRNVDDFLSISVNV 343
            .||.|.|....||||.:.....|..:|||:|.|||.....:..|....|  |....:.|:.|||:
Zfish   184 LEKKYSDPGPVYDCISWHDGVTWRAVVDTSECGDLSSCTVLSSYRERQEFCTLGFAEMLNFSVNI 248

  Fly   344 HDEGNVLEVVGMSSPHGTHVSSIASGNHSSR-DVDGVAPNAKIVSMTIGDGRLGSMETGTALVRA 407
            :||||.|.:|.....|||||:|||:|:.... :.:||||.|:|:::.|||.||.:|||||.|:||
Zfish   249 YDEGNTLCIVTSGGAHGTHVASIAAGHFPDEPERNGVAPGAQILALKIGDTRLSTMETGTGLIRA 313

  Fly   408 MTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTP 472
            |.:|:..     :.|::|.||||..:|.|||||.|::.|.|.||.|::|:||||:||.|.|||.|
Zfish   314 MIEVINY-----KCDLVNYSYGEATHWPNSGRICEVITEAVQKYNVMFVSSAGNNGPCLTTVGCP 373

  Fly   473 PDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQF 537
            ...:. |:|||||||:|.||.|||::|||||.|.|||:||.||.||..||::.||||||||||.:
Zfish   374 GGTTS-SVIGVGAYVTPDMMVAEYSLREKLPPNQYTWSSRGPCTDGALGVSISAPGGAIASVPNW 437

  Fly   538 TMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLL 602
            |:..:||||||||::|:..|.:||::|||||..:..:..:::||:..||.|:..::.||||||::
Zfish   438 TLRGTQLMNGTSMSSPNACGGIALVLSGLKQNGLRPTVPAVRRALENTAQKVEEIEVFAQGHGII 502

  Fly   603 NVEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNS-IDYNVYIEPIFYNDKEADPK 666
            .||:||::|.:|.....:.|.|||..|  :.:||:||......: .|:.|.|||||  .:..:..
Zfish   503 QVERAFDYLMQHNSLASSSLGFSVSAG--SQRGIYLRDATHVTAPSDHGVGIEPIF--PENTENA 563

  Fly   667 DKFNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLF 731
            .:.:..:.|.|:.:..||||.:.|:|....|.:.||:||.||:.|:|...:..|||..:..|.||
Zfish   564 ARISLQLHLALVCNASWVQCPSHLELMNQCRHVNVRIDPQGLREGLHYTEVCGYDTTALSAGPLF 628

  Fly   732 EIPVTVVQPHVLESDQNTPVFEPASSK-GDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNR 795
            .:|:||:.|        |.|.:..|.: ....|.|:|..|:|.||.||:.|:|||:.:   ..:.
Zfish   629 RVPITVIIP--------TKVSDSRSQELSFTDVHFRPGQIRRHFITVPQGASWAEISL---TSHT 682

  Fly   796 GEDIGKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHL 860
            |:...||.:|...|:.:::.|..|..|..|:..:.....||.|..||.||||||::|::.|...:
Zfish   683 GDVSSKFVLHAVHLVKQRAYRANEFYKFSSLLEKGSLTEAFPVLPGRTLELCIARWWASLGDVTI 747

  Fly   861 KYSLRFRGVEAHNPNAYVMHAGRGIHKLEI-EALVAEDVQPQLQLKNAEVVLKPTEAKISPLSAT 924
            .|.:.|.|: ..:|:...:||..||...|: ..|..|||.|.:.|||....|:|..:||.|| ..
Zfish   748 DYVISFHGL-VTSPSPIHIHASEGISSFEVCSPLRYEDVSPTITLKNWVQPLRPVSSKIKPL-GM 810

  Fly   925 RDVIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHS 989
            |||:|:.||:|:.:|.:|.:..|:.:|:...|:..:||||:||:||:|:|||.||.|:.:|||:.
Zfish   811 RDVLPNNRQLYELVLTYNFHQPKSGEVTPSCPLLCELLYESEFDSQLWLLFDQNKRLMGSGDAYP 875

  Fly   990 HTSFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSS 1054
            |....||:||:||:|||||||::..||::.:...|.|.:|::.|:||.||.:...::..:|  ::
Zfish   876 HQYSLKLEKGDYTVRLQVRHEQQSELERLKDLPFVVSHRLSNTLSLDVYETHRAALLAKKK--AN 938

  Fly  1055 PLRLS---TRVLYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQH------------- 1103
            .:.||   ::..||..:..:::.|.:.|.  .::||:||.|:.|.|::....             
Zfish   939 SITLSPGASQPFYITSLPDDKIPKGSGPG--GFISGSLVLPKSEFGKKAQGQASAKRQGKFKKDI 1001

  Fly  1104 -PFTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGIS 1167
             |..|.|.||..|     |.||..                 |.|                     
Zfish  1002 VPIFYHLVPAPNK-----SKNGKE-----------------KEK--------------------- 1023

  Fly  1168 VQNDPPVDSSGSPASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANL 1232
                          .|:|.|...::::|:.||.:...:.|.:   ...:|.::..|.|.||.   
Zfish  1024 --------------DPEKEKDVKEEFSEALRDLKIQWMSKLD---NSSLYEELKEAFPTHLP--- 1068

  Fly  1233 LLIQNIESNQLKSQLPLTFVNAQKTSPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSE 1297
            |.:|.:  :||                       |.:||..|:    |..||..|:.|:...|..
Zfish  1069 LHVQRL--HQL-----------------------DSEKERLKR----LPEIVSAAESVMSHIDQT 1104

  Fly  1298 ALLSYYGLKNDTRADAAKIKTNMDKQKNTLIEALSKKGIAVAKLAVLDDCIKDSLAE-------- 1354
            ||..|..:|.|.|.|||.||::|:|||.:|::||.:||.|:|     |..::..|.:        
Zfish  1105 ALAVYLTMKTDPRPDAASIKSDMEKQKASLLDALCRKGCALA-----DQLMQTPLQDGASAGQVS 1164

  Fly  1355 ------------INELYTEIIKFVDANDSKAIQFALWHAYAHGHYGRMYKYVVKLIEEKRTRDHF 1407
                        :.:.:.|:.|:.:..|||.:.|:..||.|:..|.|..||.:|::|:|.:|::.
Zfish  1165 SSEEESVGVAKALTDTFWELQKWAELTDSKVLSFSYKHALANKMYARALKYAIKIVEDKPSRENS 1229

  Fly  1408 VELAAINGALGHEHIRTVINRMMITAFPSSFRLF 1441
            .....:..:||..|..:.....:...||:.|..|
Zfish  1230 KNCLQLMRSLGWTHCVSFTESWLPILFPADFTPF 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 225/492 (46%)
Peptidase_S8 331..600 CDD:278510 138/269 (51%)
TPPII 892..1073 CDD:289357 73/183 (40%)
TPPII_N 1144..1257 CDD:289360 18/112 (16%)
tpp2XP_005168067.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 14..489 CDD:173796 225/492 (46%)
Peptidase_S8 237..500 CDD:278510 138/268 (51%)
TPPII 778..961 CDD:289357 73/185 (39%)
TPPII_N <1033..1079 CDD:289360 13/76 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596233
Domainoid 1 1.000 393 0.579 Domainoid score I740
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2471
Inparanoid 1 1.050 800 1.000 Inparanoid score I480
OMA 1 1.010 - - QHG58290
OrthoDB 1 1.010 - - D156304at2759
OrthoFinder 1 1.000 - - FOG0005779
OrthoInspector 1 1.000 - - oto39724
orthoMCL 1 0.900 - - OOG6_104037
Panther 1 1.100 - - LDO PTHR43806
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1540
SonicParanoid 1 1.000 - - X4170
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1514.840

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