DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and Pcsk9

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_705793.1	Gene:	Pcsk9 / 100102	MGIID:	2140260	Length:	694	Species:	Mus musculus

Alignment Length:	413	Identity:	99/413 - (23%)
Similarity:	156/413 - (37%)	Gaps:	133/413 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 KAVRVG-----LKSFSDLLPS---KVRNNIVAQA-KLKHWDKPHKTATANASRKIVEF-ESQNPG 255
            :|.|.|     |..|.||.|.   |:.::::..| ||.|                ||: |..:..
Mouse   104 RAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPH----------------VEYIEEDSFV 152

  Fly   256 EASKLPWDKKILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADG----WLTIVDTTEQGDLD 316
            .|..:||       ||:   .::.::.:...|          .:.||    .:.::||:.||
Mouse   153 FAQSIPW-------NLE---RIIPAWHQTEED----------RSPDGSSQVEVYLLDTSIQG--- 194

  Fly   317 QALRIGEYSRTHETR-NVDDFLSI----SVNVHDEGNVLEVVGMSSPHGTHVSSIASGNHSSRDV 376
                   ..|..|.| .:.||.|:    ....|.:.:..:      .||||::.:.||    ||.
Mouse   195 -------AHREIEGRVTITDFNSVPEEDGTRFHRQASKCD------SHGTHLAGVVSG----RDA 242

  Fly   377 DGVAPNAKIVSMTI----GDGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNS 437
             |||....:.|:.:    |.|.:.....|...:|   |...:...|..:.::.:          :
Mouse   243 -GVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIR---KSQLIQPSGPLVVLLPL----------A 293

  Fly   438 GRIGELMNEV---VNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMR 499
            |....::|..   :.:.|||.||:|||.....|...   ..|.|.:|.|||           ...
Mouse   294 GGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYS---PASAPEVITVGA-----------TNA 344

  Fly   500 EKLPGNVYT-WTSRDPCIDGGQGVTVCAPG----GAIASVPQFTMSKSQLMNGTSMAAPHVAGAV 559
            :..|..:.| .|:...|:|      :.|||    ||.:......||:|    |||.||.||||.|
Mouse   345 QDQPVTLGTLGTNFGRCVD------LFAPGKDIIGASSDCSTCFMSQS----GTSQAAAHVAGIV 399

  Fly   560 A--------LLISGLKQQNIEYS 574
            |        |.::.|:|:.|.:|
Mouse   400 ARMLSREPTLTLAELRQRLIHFS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	99/413 (24%)
		Peptidase_S8	331..600	CDD:278510	69/269 (26%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
Pcsk9	NP_705793.1	Inhibitor_I9	80..152	CDD:283552	16/63 (25%)
		Peptidases_S8_PCSK9_ProteinaseK_like	159..424	CDD:173790	81/342 (24%)
		Peptidase_S8	183..420	CDD:278510	73/294 (25%)
		C-terminal domain. /evidence=ECO:0000250	453..694
		Cell attachment site. /evidence=ECO:0000255	499..501
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900