Protein Alignment TppII and tpp2

DIOPT Version :9

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: XP_002933059.1
• Gene: tpp2 / 100101674
• XenbaseID: XB-GENE-922547
• Length: 1264
• Species: Xenopus tropicalis
• Alignment Length: 1389
• Identity: 502/1389 - (36%)
• Similarity: 765/1389 - (55%)
• Gaps: 162/1389 - (11%)

  Fly    88 MATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGLETLCDGKTVKV 152
            |..:|..|.||...|:||.|||...||.:||:||||.|.|||.|:||||.|.|::...|||. |:
 Frog     3 MMAAGAEEPFPYHGLLPKKETGAAGFLTRYPQYDGRGVLIAILDTGVDPGAPGMQQTTDGKP-KI 66

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGLKSFSDLLPSK 217
            |:..|.:|.|||:....:.| ::|.:.||||.:||:....:    :|.....:|:|:..|..|..
 Frog    67 IDIIDTTGSGDVNTSTVLEP-KDGVLVGLSGRTLKIPTRWI----NPSGKYHIGMKNGFDFYPKA 126

  Fly   218 VRNNIVAQAKLKHWDKPHKTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEMLNSYE 282
            ::..:..:.|.|.||..|:...:.|.:|..||::.:..:|..    .|::||:|..::|||||:|
 Frog   127 LKERLQKERKEKLWDPIHRAVLSEACKKQEEFDTNSNAQAQA----GKLIKEDLQSQVEMLNSFE 187

  Fly   283 KVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHE--TRNVDDFLSISVNVHD 345
            |.|.|....|||:::...:.|...:||:|.|:|:..:.:|.|..|.|  :....:.|:.|||:::
 Frog   188 KKYCDPGPVYDCLVWHDGETWRACMDTSECGNLEACIVLGNYRETQEFGSFGTAEMLNYSVNIYE 252

  Fly   346 EGNVLEVVGMSSPHGTHVSSIASGNHSSR-DVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMT 409
            |||:|.||.....|||||:|||:|..... :.:||||.|:|:::.|||.||.:|||||.|:|||.
 Frog   253 EGNLLSVVTSGGAHGTHVASIAAGYFPDEPERNGVAPGAQILAIKIGDTRLSTMETGTGLIRAMI 317

  Fly   410 KVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPPD 474
            :.::.     :.|:||.||||..:|.|||||.|.:||.|.|:.:::|:||||:||.|.|||.|..
 Frog   318 EAIKY-----KCDLINYSYGEATHWPNSGRICEAINEAVWKHNIIYVSSAGNNGPCLTTVGCPGG 377

  Fly   475 ISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTM 539
            .:. |:|||||||||.||.|||::|||||.|.|||:||.|..||..||.:.||||||||||.:|:
 Frog   378 TTS-SVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSTDGALGVCISAPGGAIASVPNWTL 441

  Fly   540 SKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNV 604
            ..:||||||||::|:..||:||::||||...|:|:.:|::||:..||.|...::.||||||::.|
 Frog   442 RGTQLMNGTSMSSPNACGAIALVLSGLKDNGIQYTVHSVRRALENTAMKAENIEVFAQGHGIIQV 506

  Fly   605 EKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQ-RNSIDYNVYIEPIFYNDKEADPKDK 668
            :||:::|.:: .|..:.:.|:|.|||:  :||:||..|| ....|:.|.|||:|  .:..:..::
 Frog   507 DKAYDYLMQN-ASLISKIGFTVTVGNS--RGIYLRDPVQVAAPSDHGVGIEPVF--PENTENSER 566

  Fly   669 FNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEI 733
            .:..:.|.|.::..|||..:.|:|....|.|.|||||.||:.|.|...|..||...:..|.||.:
 Frog   567 ISLQLHLALTSNASWVQYPSHLELMNQCRHINVRVDPRGLREGAHYTEICGYDVSALNSGPLFRV 631

  Fly   734 PVTVVQPHVLESDQNTPVFEPASSKGD---NSVEFQPNTIQRDFILVPERATWAELRMRITDPNR 795
            |:||:.|..|.          |:::.|   ..|.|:|..|:|.||.||:.|||||    :|..:|
 Frog   632 PITVIIPTQLS----------AAAECDVECKDVHFKPGQIKRHFIDVPQGATWAE----VTVSSR 682

  Fly   796 GEDI-GKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSH 859
            ..|: .||.:|..||:.:::.|..|..|..|:..:.....||.|.||:.:|.|||::|::.....
 Frog   683 SLDVSSKFVLHAVQLVKQKAYRSHEFYKFSSLPEKGSVTEAFPVLSGKTIEFCIARWWASLSDVS 747

  Fly   860 LKYSLRFRGVEAHNPNAYVMHAGRGIHKLEI-EALVAEDVQPQLQLKNAEVVLKPTEAKISPLSA 923
            :.||:.|.|:....|...: ||..||.:.:: .||..||:.|.:.|||....|:|..||..|| .
 Frog   748 IDYSISFHGLSCGMPQLNI-HASEGISRFDVHSALRYEDLSPSISLKNWVQTLRPVSAKTRPL-G 810

  Fly   924 TRDVIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAH 988
            :||::|:.||:|:.:|.:|.:..|:.:|:...|:..:||||:||:||:||::|.||..:.:|||:
 Frog   811 SRDILPNNRQLYEIILIYNFHQPKSGEVTPSCPLLCELLYESEFDSQLWMMYDQNKRQMGSGDAY 875

  Fly   989 SHTSFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVS 1053
            .|....||:||:||||:|||||:...||::.:...|.|.::::.|:||.||.::..::|.:|..|
 Frog   876 PHQYSVKLEKGDYTIRMQVRHEQISELERLKDLPFVVSHRMSNTLSLDIYETHSMALLGKKKANS 940

  Fly  1054 SPLRLS-TRVLYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQHPFTYILNPAEKKSH 1117
            ..|... ::..::..:..:::.|...|.  .:|:|.|...:.|:|::.
 Frog   941 QTLPPKYSQPFFVTMLPDDKIPKGAGPG--CYLAGTLTLSKTELGKKA----------------- 986

  Fly  1118 TNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQND--PPVD--SSG 1178
                  |.|||          ...|...|                 |.|||...  ||..  .:|
 Frog   987 ------GQSAA----------KRQGKFKK-----------------DVISVHYHLIPPSSKPKNG 1018

  Fly  1179 SPASPKKGKANAD---DYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANLLLIQNIES 1240
            :....|:.:...|   :|||:.||.:...:.|.|   :..|:.|:..|:|.||...:..:..:
 Frog  1019 TKEKEKEAEKEKDVKEEYAEALRDLKIQWMSKLE---SSDIFTDLKEAYPNHLPLYVARLHQL-- 1078

  Fly  1241 NQLKSQLPLTFVNAQKTSPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSEALLSYYGL 1305
                                      |.:|:..|::...||    .::.||...|..||..:..:
 Frog  1079 --------------------------DSEKDRLKRIHEILE----ASNDVILRIDQTALAVFLAM 1113

  Fly  1306 KNDTRADAAKIKTNMDKQKNTLIEALSKKGIAVA-KLAVL---------------DD--CIKDSL 1352
            |.|.|.|||.||.:|||||:|||:||.:||.|:| ||..|               ||  .|.|:|
 Frog  1114 KTDPRPDAATIKNDMDKQKSTLIDALCRKGCALADKLIHLQSEEGAASGDAEKKEDDQEAISDAL 1178

  Fly  1353 AEINELYTEIIKFVDANDSKAIQFALWHAYAHGHYGRMYKYVVKLIEEKRTRDHFVELAAINGAL 1417
               ||.|.|::|:.|.:|||.:.|...||.|:..|||..|:..||:|||.|::::.....|...|
 Frog  1179 ---NETYWEVVKWADLSDSKVLPFVYKHALANKLYGRGIKFATKLVEEKPTKENWKNCIQIMKFL 1240

  Fly  1418 GHEHIRTVINRMMITAFPSSFRLF 1441
            |..|..:.....|...:|..:.:|
 Frog  1241 GWTHSASFTENWMPVMYPPDYSVF 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	219/490 (45%)
		Peptidase_S8	331..600	CDD:278510	140/269 (52%)
		TPPII	892..1073	CDD:289357	68/181 (38%)
		TPPII_N	1144..1257	CDD:289360	23/119 (19%)
tpp2	XP_002933059.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	16..491	CDD:173796	219/490 (45%)
		TPPII	779..962	CDD:378883	68/183 (37%)
		TPPII_N	<1036..1080	CDD:372205	13/74 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I744
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2471
Inparanoid	1	1.050	807	1.000	Inparanoid score	I478
OMA	1	1.010	-	-		QHG58290
OrthoDB	1	1.010	-	-		D156304at2759
OrthoFinder	1	1.000	-	-		FOG0005779
OrthoInspector	1	1.000	-	-		oto104980
Panther	1	1.100	-	-	LDO	PTHR43806
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1540
SonicParanoid	1	1.000	-	-		X4170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110