DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and TNK1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001238831.1	Gene:	TNK1 / 8711	HGNCID:	11940	Length:	666	Species:	Homo sapiens

Alignment Length:	699	Identity:	202/699 - (28%)
Similarity:	302/699 - (43%)	Gaps:	153/699 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            |.:.|.:.:|.|:|..:..||.:|....|.:...|||..||:.||..|||.:            .
Human    10 LLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSE------------A 62

  Fly    73 IKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNN----KHIIPADSI 133
            :|||...|.:.....:..||.:....:.:..|           .||..:|..    |.:||..::
Human    63 LKRLRSGPKSKNWVYKILGGFAPEHKEPTLPS-----------DSPRHLPEPEGGLKCLIPEGAV 116

  Fly   134 SVNKQLGTGEFGIVQQGVWS-NGNERIQVAIKCLCRERM-QSNPM-----EFLKEAAIMHSIEHE 191
            ...:.||:|.||:|.:|:|: ...:.:.||:|.|   |: ...||     :||:|.::|.::||.
Human   117 CRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSL---RVGPEGPMGTELGDFLREVSVMMNLEHP 178

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPT---------LCEFALQICNG 247
            :::||:|:||. ..|.:|.|||.|.||          .:.||.|.         ||.|..|:...
Human   179 HVLRLHGLVLG-QPLQMVMELAPLGSL----------HARLTAPAPTPPLLVALLCLFLRQLAGA 232

  Fly   248 MRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECI 312
            |.||..:.|:|||||.||:|:.|...:|::||||.|.||..:..|.  ......:|.||||||.:
Human   233 MAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYV--MGGPRPIPYAWCAPESL 295

  Fly   313 NYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMK 377
            .:..|::|||||.|||.||||||.|.:|||.:....||:.::  :..||.:|..|....|:|.::
Human   296 RHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE--DRARLPRPPLCSRALYSLALR 358

  Fly   378 CWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTG-----TPF 437
            ||....|.||.|..:...|.:..|.:...|.:.|||  ..|....||.|:|::.::.     :..
Human   359 CWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEP--GALRMETGDPITVIEGSSSFHSPDSTI 421

  Fly   438 WKGVLS-TGKTGYFNPSNTVAFLE--GLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTG 499
            |||... |.|.|.| |::.|...:  ||| :||..      ||           ..|....:|.|
Human   422 WKGQNGRTFKVGSF-PASAVTLADAGGLP-ATRPV------HR-----------GTPARGDQHPG 467

  Fly   500 HVGIDG----ATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIE---QTPLLLPPTPT----SPDS 553
              .|||    |...| |.....|..|       .|.:..:.|.   ::.|.|.|.||    ||..
Human   468 --SIDGDRKKANLWD-APPARGQRRN-------MPLERMKGISRSLESVLSLGPRPTGGGSSPPE 522

  Fly   554 LQTASGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELE 618
            ::.|.. .|:|.               |.....|.|           :|.|..|..|:|  :.|.
Human   523 IRQARA-VPQGP---------------PGLPPRPPL-----------SSSSPQPSQPSR--ERLP 558

  Fly   619 FGLHNYGADGKSVHSETGWRPTSR-------SIVDDPHEYHEISDDEIA 660
            :      ...|..|:.....|.:|       .::.||....:|.:.|::
Human   559 W------PKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	19/56 (34%)
		STYKc	133..396	CDD:214568	103/278 (37%)
		PTKc_Ack_like	137..398	CDD:270636	104/276 (38%)
		SH3	400..454	CDD:214620	18/59 (31%)
		CRIB	486..525	CDD:238077	11/42 (26%)
TNK1	NP_001238831.1	SAM_TNK-like	6..67	CDD:188938	21/68 (31%)
		STYKc	119..377	CDD:214568	103/275 (37%)
		PKc_like	120..379	CDD:304357	104/276 (38%)
		SH3	385..441	CDD:214620	17/58 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..493		18/74 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..579		23/107 (21%)
		UBA_like_SF	594..637	CDD:304366	2/8 (25%)
		UBA_TNK1	624..663	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820