DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Tnk1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_114086.3	Gene:	Tnk1 / 83813	MGIID:	1930958	Length:	666	Species:	Mus musculus

Alignment Length:	690	Identity:	203/690 - (29%)
Similarity:	299/690 - (43%)	Gaps:	129/690 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            |...|.:.:|.|:|..:..||.:|....|.:...|||..||:.||..|||.:..::     |.|.
Mouse    10 LLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKR-----YRSG 69

  Fly    73 IK------RLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPAD 131
            :|      ::|  .|...:::|.|        ..|.:..|.. ..:.|.         |.:||..
Mouse    70 VKSKNWVYKIL--GGFAPEQKEIP--------PRSDSPLCFH-EPEGGL---------KCLIPEG 114

  Fly   132 SISVNKQLGTGEFGIVQQGVWS-NGNERIQVAIKCLCRERM-QSNPM-----EFLKEAAIMHSIE 189
            ::...:.||:|.||:|.:|:|: ...:.|.||:|.|   |: ...||     :||:|.::|..:|
Mouse   115 AVRRGELLGSGCFGVVHRGLWTLPSGQSIPVAVKSL---RVGPEGPMGTELGDFLREVSVMMKLE 176

  Fly   190 HENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPT---------LCEFALQIC 245
            |.:::||:|:||. ..|.:|.|||.|.||          .:.||.|.         ||.|..|:.
Mouse   177 HPHVLRLHGLVLG-QPLQMVMELAPLGSL----------HARLTAPAPTPPLPVALLCLFLRQLA 230

  Fly   246 NGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPE 310
            ..|.||....|:|||||.||:|:.|...:|::||||.|.||..:..|.  ......:|.||||||
Mouse   231 GAMAYLGSCGLVHRDLATRNLLLASPRMIKVADFGLVRPLGGARGRYV--MGGPRPIPYAWCAPE 293

  Fly   311 CINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLM 375
            .:....|::|||||.|||.||||||.|.:|||.:....||:.:: .:..||.:|..|....|:|.
Mouse   294 SLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-KDRARLPKPPLCSRALYSLA 357

  Fly   376 MKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKG 440
            ::||....|.||.|..:...|.:....:.:.|...|||  ..|....||.|::::.:..|..|||
Mouse   358 LRCWAPHPADRPSFSNLEGLLQEAWLSEGRCVREVTEP--GALRMEPGDPITIIEGSLDTATWKG 420

  Fly   441 VLSTGKT---GYFNPSN-TVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHV 501
              ..|:|   |.|..|. |:|.|.|.|.:.       ..||           ..|.:..|..|
Mouse   421 --QNGRTLKVGNFPASAVTLADLGGSPVTH-------PAHR-----------GSPAHGEKCRG-- 463

  Fly   502 GIDG----ATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFP 562
            |.||    ||..|:.  .:..:...:|.|.:...  |:.:|.. |.|.|.|       |..|..|
Mouse   464 GTDGDREKATLQDLP--PARSHRTKMPLQRMRGI--SKSLESV-LSLGPRP-------TGGGSSP 516

  Fly   563 EGANSGGAMGTSMN--PTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNY- 624
            .......||...:.  |...|.....|.:|..:.|           |..|::...:.| ..||:
Mouse   517 PELRRTRAMPQRLPDLPPRPPDLPPRPPIICNSSQ-----------PTQPHKARPKRE-SSHNHR 569

  Fly   625 -GADGKSVHSETGWRPTS-----RSIVDDPHEYHEISDDE 658
             ||.|.|..:.....|.|     |.:|:.....|.::..|
Mouse   570 TGAPGASKATVPSGGPLSDPEWQRKVVEVELSVHGVTYQE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	19/56 (34%)
		STYKc	133..396	CDD:214568	104/278 (37%)
		PTKc_Ack_like	137..398	CDD:270636	105/276 (38%)
		SH3	400..454	CDD:214620	16/56 (29%)
		CRIB	486..525	CDD:238077	9/42 (21%)
Tnk1	NP_114086.3	SAM_TNK-like	16..67	CDD:188938	17/55 (31%)
		PKc_like	120..380	CDD:389743	105/276 (38%)
		SH3	<395..436	CDD:388381	14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..589		42/190 (22%)
		UBA_like_SF	594..637	CDD:389751	3/16 (19%)
		UBA_like_SF	624..663	CDD:389751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810