DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Frk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_077344.1	Gene:	Frk / 79209	RGDID:	621423	Length:	506	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	108/272 - (39%)
Similarity:	168/272 - (61%)	Gaps:	12/272 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            |..:||.:.|:||:|:||.|.:|:|:|   ...||:|.|....|  :|.:||:||.||.|:.|..
  Rat   230 IDRNSIQLLKRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGSM--DPNDFLREAQIMKSLRHPK 289

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :::||.|....|.:.::|||....||.|.|::.|  .|.:.:....:.|.|:.:||.|||.:..|
  Rat   290 LIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDG--GSKIRLTQQVDMAAQVASGMAYLESQNYI 352

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGV-GKDYYKTNFNVNLKLPIAWCAPECINYLRFTNAS 321
            ||||||||:||...:..|::||||:|...| .:|.|::...:  |||:.|.|||.|...:|:..|
  Rat   353 HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEI--KLPVKWTAPEAIRTNKFSIKS 415

  Fly   322 DVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKR 386
            |||:||:.|:|:.:||..|::.:||.|::..: ..|| ||.||..||.::|::||:||..:..:|
  Rat   416 DVWSFGILLYEIITYGKMPYSGMTGAQVIHML-GQNY-RLPQPSNCPEQFYSIMMECWNVEPKQR 478

  Fly   387 PRFGEIYDQLPD 398
            |.|..::.:|.|
  Rat   479 PTFETLHWKLED 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	104/263 (40%)
		PTKc_Ack_like	137..398	CDD:270636	104/261 (40%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Frk	NP_077344.1	SH3_Src_like	48..105	CDD:212779
		SH2_Src_Frk	113..208	CDD:199831
		PTKc_Frk_like	226..495	CDD:270653	108/272 (40%)
		Pkinase_Tyr	235..488	CDD:285015	104/263 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920