DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Fgfr1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_077060.1	Gene:	Fgfr1 / 79114	RGDID:	620713	Length:	822	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	107/370 - (28%)
Similarity:	179/370 - (48%)	Gaps:	38/370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IRRLRKFYEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGS---------SASACSSL 109
            |.:::...:|...||.::..|.....|   ::|:......|..:::..         |:|....|
  Rat   396 IYKMKSGTKKSDFHSQMAVHKLAKSIP---LRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPML 457

  Fly   110 AAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFG--IVQQGVW---SNGNERIQVAIKCLCRE 169
            |   |.|......:.:..:|.|.:.:.|.||.|.||  ::.:.:.   ...|...:||:|.|..:
  Rat   458 A---GVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 519

  Fly   170 RMQSNPMEFLKEAAIMHSI-EHENIVRLYGVVLATDSLMLVTELA---HLRSLLECLKDSGLRVS 230
            ..:.:..:.:.|..:|..| :|:||:.|.|.......|.::.|.|   :||..|:..:..||...
  Rat   520 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYC 584

  Fly   231 F---------LTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALG 286
            :         |:...|...|.|:..||.||..|:.|||||||||:||...:.:||:||||:|.:.
  Rat   585 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 649

  Fly   287 VGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILE 351
             ..||||.  ..|.:||:.|.|||.:....:|:.||||:|||.|||:|:.|..|...:...::.:
  Rat   650 -HIDYYKK--TTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFK 711

  Fly   352 AIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            .:...:  |:::|..|.:|.|.:|..||....::||.|.::.:.|
  Rat   712 LLKEGH--RMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	2/10 (20%)
		STYKc	133..396	CDD:214568	90/280 (32%)
		PTKc_Ack_like	137..398	CDD:270636	91/278 (33%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Fgfr1	NP_077060.1	Ig1_FGFR	40..118	CDD:143174
		IG_like	41..118	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162
		I-set	160..247	CDD:254352
		Heparin-binding	160..177
		Ig2_FGFR	163..247	CDD:143265
		IG_like	262..358	CDD:214653
		Ig3_FGFR	270..359	CDD:143175
		PTKc_FGFR1	464..765	CDD:270678	93/296 (31%)
		Pkinase_Tyr	478..754	CDD:285015	90/280 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910