DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Fgr

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_077059.2	Gene:	Fgr / 79113	RGDID:	621319	Length:	517	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	109/297 - (36%)
Similarity:	158/297 - (53%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            |..:||:::::||||.||.|..|.|   |...:||:|.|....|  :|..||:||.||..:.|:.
  Rat   246 IDRNSIALDRRLGTGCFGDVWLGTW---NCSTKVAVKTLKPGTM--SPKAFLEEAQIMKLLRHDK 305

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|:||.|| :.:.:.:|||.....|||:.|||.  :...|.:|.|.:.|.|:..||.|:|:...|
  Rat   306 LVQLYAVV-SEEPIYIVTEFMCYGSLLDFLKDR--KGHNLMLPNLVDMAAQVAEGMAYMERMNYI 367

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||.|.||||......||:||||:|.: |..:|   |.....|.||.|.|||...:.|||..||
  Rat   368 HRDLRAANILVGEHLICKIADFGLARLI-VDDEY---NPQQGTKFPIKWTAPEAALFGRFTVKSD 428

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            ||:||:.|.|:.:.|..|:..:...::||.::  :...:..|..||...|.:|.:.|:.|..:||
  Rat   429 VWSFGILLTELITKGRVPYPGMNNREVLEQVE--HGYHMPCPPGCPVSLYEVMEQTWRLDPEERP 491

  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            .|..:...|.|        ....|||:     |:.||
  Rat   492 TFEYLQSFLED--------YFTSTEPQ-----YQPGD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	99/262 (38%)
		PTKc_Ack_like	137..398	CDD:270636	99/260 (38%)
		SH3	400..454	CDD:214620	6/25 (24%)
		CRIB	486..525	CDD:238077
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..46
		SH3	68..125	CDD:418401
		SH2_Src_Fgr	128..228	CDD:198230
		PKc_like	255..502	CDD:419665	99/260 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010