DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and tyro3

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_012824144.1	Gene:	tyro3 / 780188	XenbaseID:	XB-GENE-922144	Length:	906	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	117/374 - (31%)
Similarity:	180/374 - (48%)	Gaps:	46/374 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EKHFPH---SYLSKIKRLLQAPGTMVK---------REEAPGGGSQVALDGSSASACSSLAAKN- 113
            ::| ||   |::..:..:|.|..|:|.         |:|...|....::.|.........||::
Frog   430 QRH-PHTRMSWVPMVLGILTALVTVVAMTLIFLRKGRKETRFGNMLGSMLGRGGPVIQFTAARSF 493

  Fly   114 ---------------GASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQ-VA 162
                           |.|...|......:|.....::.:.||.||||.|::......::.:| ||
Frog   494 NRRGPEVMEATLDSIGISDELKSKLKDVLIQQQQFTLGRTLGKGEFGSVREAQLKMEDDTMQKVA 558

  Fly   163 IKCLCRERMQSNPM-EFLKEAAIMHSIEHENIVRLYGVVLATDS-------LMLVTELAH--LRS 217
            :|.|..|...|:.: |||:|||.|...:|.|:.:|.||.|.:.:       ::::..:.|  |.:
Frog   559 VKMLKAEIFCSSDIEEFLREAAFMKEFDHPNVCKLIGVSLRSRTKGRLPVPMVILPFMKHGDLHT 623

  Fly   218 LLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLS 282
            .| .:...|.....|.|.||..|.:.||:||.||..|..||||||.||.::.....|.::|||||
Frog   624 FL-LMSRIGEEPIALPIQTLVRFMIDICSGMEYLSSKNFIHRDLATRNCMLNEDMTVCVADFGLS 687

  Fly   283 RALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGL 347
            :.:..| |||:.  ....|||:.|.|.|.:....:|..||||||||.|||:.:.|..|:|.:...
Frog   688 KKIYSG-DYYRQ--GCASKLPVKWLALESLADNVYTVHSDVWAFGVTLWEIVTRGQTPYAGVENS 749

  Fly   348 QILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            :|...:.|.|  ||:||..|..|.|.:|.:||..:..:||.|.::..:|
Frog   750 EIYSYLTAGN--RLKQPPDCLDELYEMMCQCWITEPKRRPSFVDLKRRL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	0/2 (0%)
		STYKc	133..396	CDD:214568	98/273 (36%)
		PTKc_Ack_like	137..398	CDD:270636	99/271 (37%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
tyro3	XP_012824144.1	I-set	31..116	CDD:254352
		IGc2	42..108	CDD:197706
		Ig2_Tyro3_like	127..206	CDD:143226
		IG_like	131..207	CDD:214653
		FN3	211..328	CDD:238020
		fn3	337..416	CDD:278470
		PTKc_Tyro3	518..801	CDD:270659	100/285 (35%)
		Pkinase_Tyr	528..796	CDD:285015	98/273 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910