DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and ptk6b

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001070140.1	Gene:	ptk6b / 767734	ZFINID:	ZDB-GENE-060929-1150	Length:	511	Species:	Danio rerio

Alignment Length:	407	Identity:	120/407 - (29%)
Similarity:	190/407 - (46%)	Gaps:	66/407 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYE-----KHFPHSYLS 71
            ::||:...|..:|:.:   .||..||.....|..::.       .|.||..     :|:....||
Zfish   162 VSESDDMGYVLSVRTK---ENAKHFKIFQTGDQFYVD-------ALFKFSSIVEVIEHYQSHPLS 216

  Fly    72 KIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVN 136
             |..||..|...:|.|..|                          .||   .::..:|.:...:.
Zfish   217 -IGDLLSEPCIRIKPENVP--------------------------PPS---TDEWELPKEEFQLE 251

  Fly   137 KQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNP----MEFLKEAAIMHSIEHENIVRLY 197
            .|||:|.|..|..|.|.|.:   :||||.|     ::|.    .||..|..||..:.|::::.|:
Zfish   252 NQLGSGHFADVYSGKWKNHS---KVAIKIL-----KNNDALVLREFQLEVQIMKRLRHKHLISLF 308

  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLA 262
            .|..::....::|||.....||..|::...|  .|.:.:|.:.|.|:.:||.|||....||||||
Zfish   309 AVCTSSSPFYIITELIEKGDLLHFLRNPEGR--SLQMESLIDMAAQVADGMAYLEANNSIHRDLA 371

  Fly   263 ARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFG 327
            |||:||......||:||||:|.  :.:..|.::   :.|:|..|.|||.|.:..:::.||||:||
Zfish   372 ARNVLVGDGYVCKIADFGLARI--IKEPVYLSD---DKKIPYKWTAPEAIGHGTYSSKSDVWSFG 431

  Fly   328 VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392
            :.|:|:.::|..|:..:...::.:.|...|| |:..|..||...|.:|..||:.::..||.|..:
Zfish   432 ILLYEIVTHGGIPYPGVNTGEVYDLITKENY-RMPSPPKCPQAIYNIMRACWRIESVDRPNFKVL 495

  Fly   393 YDQLPDMKPEQLKAVVN 409
            .|:| |....|..:|.|
Zfish   496 KDEL-DNYQGQYSSVGN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	12/57 (21%)
		STYKc	133..396	CDD:214568	90/266 (34%)
		PTKc_Ack_like	137..398	CDD:270636	91/264 (34%)
		SH3	400..454	CDD:214620	3/10 (30%)
		CRIB	486..525	CDD:238077
ptk6b	NP_001070140.1	SH3_Brk	70..126	CDD:212781
		SH2	132..216	CDD:214585	13/63 (21%)
		PTKc_Srm_Brk	241..502	CDD:133248	93/277 (34%)
		STYKc	250..499	CDD:214568	90/264 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010