DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and YES1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_005424.1	Gene:	YES1 / 7525	HGNCID:	12841	Length:	543	Species:	Homo sapiens

Alignment Length:	297	Identity:	111/297 - (37%)
Similarity:	154/297 - (51%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            ||.:|:.:..:||.|.||.|..|.| ||..:  ||||.|....|.  |..||:||.||..:.|:.
Human   272 IPRESLRLEVKLGQGCFGEVWMGTW-NGTTK--VAIKTLKPGTMM--PEAFLQEAQIMKKLRHDK 331

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|.||.|| :.:.:.:|||.....|||:.||:...:  :|.:|.|.:.|.||.:||.|:|:...|
Human   332 LVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGK--YLKLPQLVDMAAQIADGMAYIERMNYI 393

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||.|.||||......||:||||:|.: ...:|   ......|.||.|.|||...|.|||..||
Human   394 HRDLRAANILVGENLVCKIADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGRFTIKSD 454

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            ||:||:...|:.:.|..|:..:...::||.::. .| |:..|..||...:.||..||:.|..:||
Human   455 VWSFGILQTELVTKGRVPYPGMVNREVLEQVER-GY-RMPCPQGCPESLHELMNLCWKKDPDERP 517

  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            .|..|...|.|        ....|||:     |:.|:
Human   518 TFEYIQSFLED--------YFTATEPQ-----YQPGE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	101/262 (39%)
		PTKc_Ack_like	137..398	CDD:270636	102/260 (39%)
		SH3	400..454	CDD:214620	5/25 (20%)
		CRIB	486..525	CDD:238077
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		SH3_Yes	94..151	CDD:212940
		SH2_Src_family	154..253	CDD:199827
		PTKc_Yes	264..542	CDD:270654	111/297 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920