DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and SYK

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001167638.1	Gene:	SYK / 6850	HGNCID:	11491	Length:	635	Species:	Homo sapiens

Alignment Length:	278	Identity:	104/278 - (37%)
Similarity:	160/278 - (57%)	Gaps:	18/278 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPM---EFL 179
            |.:|..::.::..:    :|:||:|.||.|::|.:........||:|.|..|  .::|.   |.|
Human   360 PKEVYLDRKLLTLE----DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE--ANDPALKDELL 418

  Fly   180 KEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQI 244
            .||.:|..:::..|||:.|:..| :|.|||.|:|.|..|.:.|:.:    ..:....:.|...|:
Human   419 AEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQN----RHVKDKNIIELVHQV 478

  Fly   245 CNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAP 309
            ..||:|||:...:||||||||:|:.::...||||||||:||...::|||.  ..:.|.|:.|.||
Human   479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA--QTHGKWPVKWYAP 541

  Fly   310 ECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTL 374
            |||||.:|::.||||:|||.:||.||||.:|:..:.|.::...::  ..:|:..|..||.|.|.|
Human   542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE--KGERMGCPAGCPREMYDL 604

  Fly   375 MMKCWQDDAAKRPRFGEI 392
            |..||..|...||.|..:
Human   605 MNLCWTYDVENRPGFAAV 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	102/263 (39%)
		PTKc_Ack_like	137..398	CDD:270636	102/259 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
SYK	NP_001167638.1	SH2_N-SH2_Zap70_Syk_like	13..116	CDD:198191
		Interdomain A	108..167
		SH2_C-SH2_Syk_like	164..262	CDD:198264
		Interdomain B	260..370		2/9 (22%)
		PTKc_Syk	375..631	CDD:133247	102/259 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910