DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack-like and SRMS

DIOPT Version :10

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:NP_543013.1 Gene:SRMS / 6725 HGNCID:11298 Length:488 Species:Homo sapiens


Alignment Length:425 Identity:126/425 - (29%)
Similarity:199/425 - (46%) Gaps:86/425 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 ITNAAQF--KYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAPGT----MVKREE 88
            ||:.|:.  :..:|:...|.|:||.:.::|                  ||..|..    :::..|
Human   104 ITHVAKASPETLSDQPWYFSGVSRTQAQQL------------------LLSPPNEPGAFLIRPSE 150

  Fly    89 APGGGSQVALDGS--------SASACSSLAAKNGASSPS------------KVPNNKHIIPA--- 130
            :..||..:::...        |.:|..||..:.|...|.            |:..|..:.|.   
Human   151 SSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQ 215

  Fly   131 ------------DSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAA 183
                        ...::.::||.|.||.|.:|:|...   :.||||.:....|:..  :..||..
Human   216 KAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGS---LPVAIKVIKSANMKLT--DLAKEIQ 275

  Fly   184 IMHSIEHENIVRLYGVVLATDSLMLVTEL---AHLRSLLECLKDSGLRVSFLTIPTLCEFALQIC 245
            .:..:.||.::||:.|....:.:.:||||   .:|::.|...:...||     :|.|..||.|:.
Human   276 TLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALR-----LPPLLGFACQVA 335

  Fly   246 NGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPE 310
            .||.|||::|::||||||||:||......|::||||:|.|  ..|.|..  :.:.|:|:.|.|||
Human   336 EGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLL--KDDIYSP--SSSSKIPVKWTAPE 396

  Fly   311 CINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLM 375
            ..||..|:..||||:|||.|.|:|:||..|:..:|..:.|:.| ...| ||.:|..||:|.|.||
Human   397 AANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQI-MRGY-RLPRPAACPAEVYVLM 459

  Fly   376 MKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNC 410
            ::||:....:||.|..:        .|:|.|:..|
Human   460 LECWRSSPEERPSFATL--------REKLHAIHRC 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938 9/36 (25%)
PTKc_Ack_like 137..398 CDD:270636 98/263 (37%)
SH3 400..454 CDD:214620 4/11 (36%)
CRIB 486..525 CDD:238077
SRMSNP_543013.1 SH3_Srms 55..109 CDD:212780 2/4 (50%)
SH2 119..197 CDD:472789 17/95 (18%)
PTKc_Srm_Brk 223..483 CDD:133248 100/283 (35%)
Blue background indicates that the domain is not in the aligned region.

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