DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and SRMS

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens

Alignment Length:	425	Identity:	126/425 - (29%)
Similarity:	199/425 - (46%)	Gaps:	86/425 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ITNAAQF--KYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAPGT----MVKREE 88
            ||:.|:.  :..:|:...|.|:||.:.::|                  ||..|..    :::..|
Human   104 ITHVAKASPETLSDQPWYFSGVSRTQAQQL------------------LLSPPNEPGAFLIRPSE 150

  Fly    89 APGGGSQVALDGS--------SASACSSLAAKNGASSPS------------KVPNNKHIIPA--- 130
            :..||..:::...        |.:|..||..:.|...|.            |:..|..:.|.
Human   151 SSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQ 215

  Fly   131 ------------DSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAA 183
                        ...::.::||.|.||.|.:|:|...   :.||||.:....|:..  :..||..
Human   216 KAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGS---LPVAIKVIKSANMKLT--DLAKEIQ 275

  Fly   184 IMHSIEHENIVRLYGVVLATDSLMLVTEL---AHLRSLLECLKDSGLRVSFLTIPTLCEFALQIC 245
            .:..:.||.::||:.|....:.:.:||||   .:|::.|...:...||     :|.|..||.|:.
Human   276 TLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALR-----LPPLLGFACQVA 335

  Fly   246 NGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPE 310
            .||.|||::|::||||||||:||......|::||||:|.|  ..|.|..  :.:.|:|:.|.|||
Human   336 EGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLL--KDDIYSP--SSSSKIPVKWTAPE 396

  Fly   311 CINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLM 375
            ..||..|:..||||:|||.|.|:|:||..|:..:|..:.|:.| ...| ||.:|..||:|.|.||
Human   397 AANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQI-MRGY-RLPRPAACPAEVYVLM 459

  Fly   376 MKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNC 410
            ::||:....:||.|..:        .|:|.|:..|
Human   460 LECWRSSPEERPSFATL--------REKLHAIHRC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	9/36 (25%)
		STYKc	133..396	CDD:214568	98/265 (37%)
		PTKc_Ack_like	137..398	CDD:270636	98/263 (37%)
		SH3	400..454	CDD:214620	4/11 (36%)
		CRIB	486..525	CDD:238077
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	2/4 (50%)
		SH2	119..197	CDD:301589	17/95 (18%)
		PTKc_Srm_Brk	223..483	CDD:133248	100/283 (35%)
		STYKc	232..480	CDD:214568	99/271 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920