DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and SRC

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_016883513.1	Gene:	SRC / 6714	HGNCID:	11283	Length:	542	Species:	Homo sapiens

Alignment Length:	317	Identity:	112/317 - (35%)
Similarity:	164/317 - (51%)	Gaps:	41/317 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSKVPNNKHI------IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPM 176
            |:..|..:.:      ||.:|:.:..:||.|.||.|..|.| ||..|  ||||.|....|  :|.
Human   255 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW-NGTTR--VAIKTLKPGTM--SPE 314

  Fly   177 EFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFA 241
            .||:||.:|..:.||.:|:||.|| :.:.:.:|||.....|||:.||  |....:|.:|.|.:.|
Human   315 AFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLK--GETGKYLRLPQLVDMA 376

  Fly   242 LQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAW 306
            .||.:||.|:|:...:||||.|.||||......|::||||:|.: ...:|   ......|.||.|
Human   377 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEY---TARQGAKFPIKW 437

  Fly   307 CAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEY 371
            .|||...|.|||..||||:||:.|.|:.:.|..|:..:...::|:.::. .| |:..|..||...
Human   438 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GY-RMPCPPECPESL 500

  Fly   372 YTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVV----NCTEPKKDHLLYRQGD 424
            :.||.:||:.:..:||.|            |.|:|.:    ..|||:     |:.|:
Human   501 HDLMCQCWRKEPEERPTF------------EYLQAFLEDYFTSTEPQ-----YQPGE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	99/262 (38%)
		PTKc_Ack_like	137..398	CDD:270636	99/260 (38%)
		SH3	400..454	CDD:214620	8/29 (28%)
		CRIB	486..525	CDD:238077
SRC	XP_016883513.1	SH3_Src	88..149	CDD:212941
		SH2_Src_Src	153..253	CDD:198228
		PTKc_Src	266..542	CDD:270656	110/306 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010