DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Myo3a

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_680779.3	Gene:	Myo3a / 667663	MGIID:	2183924	Length:	1621	Species:	Mus musculus

Alignment Length:	1382	Identity:	252/1382 - (18%)
Similarity:	450/1382 - (32%)	Gaps:	459/1382 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSI-EHEN 192
            |:|:..:.:.:|.|.:|.|.:.:  |.....:.|:|.|  :.:.....|...|..|:.:: :|.|
Mouse    25 PSDTWEIIETIGKGTYGKVFKVL--NKKSGQKAAVKIL--DPIHDIDEEIEAEYNILRTLSDHPN 85

  Fly   193 IVRLYGVV-----LATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLE 252
            :||.||:.     :..|.|.||.||.:..|:.:.:|....|...::.|.:.....:...|:::|.
Mouse    86 VVRFYGIYFKKDKINGDKLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMGLQHLH 150

  Fly   253 QKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPE---CINY 314
            ..:.||||:...|||:.::..||:.|||:|..|...:.    ..|.::..|. |.|||   |...
Mouse   151 SNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRH----RLNTSVGTPF-WMAPEVIACEQQ 210

  Fly   315 LRFTNAS--DVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMK 377
            |..|..:  |.|:.|:...|: ..|..|.|.|..::.|..|......:|.||:...:|:...:.|
Mouse   211 LDTTYDARCDTWSLGITAIEL-GDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISK 274

  Fly   378 CWQDDAAKRPRFGEIYD--------------QLPDMKPEQLKAVVNCTEPKKDHLLY-RQGDI-- 425
            |...|..|||...::..              |...|:...:...:..||..:...:: ::|::
Mouse   275 CLTKDYEKRPTVSDLLKHKFITQIEGKDVILQKQLMEFIDIHQCLGSTEKARHERIHTKKGNLNR 339

  Fly   426 --------------ISVLDRNTGT------------------------PFWK-GVLST------- 444
                          :.|||.||.:                        ||.. |:.||
Mouse   340 SLISSLKDVDDLATLDVLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSLGIYSTKLSRLYI 404

  Fly   445 GKTGYFNPSNTVAF----LEGLPSSTRDSFSRVSDHR-----------------ISKRKLRT--E 486
            |.....||.:..|.    .:.:.:...|....:|...                 :.|...||  |
Mouse   405 GAKRTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVLGKANNRTLQE 469

  Fly   487 MISKPQN-----------------------DFKHTGHVGIDGATFGDIAFLGS--------SQNY 520
            .|.:..|                       :.|.|....:.||...:.....|        .:|:
Mouse   470 KILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNF 534

  Fly   521 NHV---------PKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMN 576
             |:         .|:.:..||..|:       .||.....|:|:|..              ..||
Mouse   535 -HIFYYIYAGLAEKKKLALYKLPEN-------KPPRYLQNDNLRTVQ--------------DMMN 577

  Fly   577 PTFIPS----AEHTPKLI---------------ATNGQSSFDFASGST-----------NPFFPN 611
            .:|..|    .|...|:|               |.....:.:|:|.:|           :....|
Mouse   578 NSFYKSQYELIEQCFKVIGFTMEQLGSVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALEN 642

  Fly   612 RGD------DELEFGLHNYGADGKSVHSETGWRPTSRSIVD------DPHEYHEISDDEIAADKL 664
            ...      |||:..|                  ||..:|.      .|:...:.:|...|..|.
Mouse   643 SASLLCIQADELQEAL------------------TSHCVVTRGETIIRPNTVEKAADVRDAMAKT 689

  Fly   665 DFG---PSLLDEINSMFGSISAATGSHPKSPGFDHVNN-------------KNEITEMSAKLGQK 713
            .:|   ..:::.|||:.        .|..||..|...|             :|...::...:..:
Mouse   690 LYGRLFSWIVNCINSLL--------KHDTSPSGDEELNIGILDIFGFENFKRNSFEQLCINIANE 746

  Fly   714 SGDTNGNKHGHGLLPTLSKKKS-----SGTVKPISVKDEK-----ILNHAIEIANEISARSMIDL 768
            ......|:|      ..:.:::     ....:.|..:|.:     .|...:.:.:.:...|....
Mouse   747 QIQYYFNQH------VFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLSLLDEESRFPK 805

  Fly   769 VSDQTPV-----------IHSPKR-KFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPK 821
            .:|||.:           ...||| :.||...|.:.......||.|..          |...||
Mouse   806 ATDQTLIEKFEDNLKSQYFWRPKRMELSFGIHHYAGKVLYSASGFLAK----------NRDTFP- 859

  Fly   822 KKNFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPL----NLERECG 882
                                      ||:.:.:...|:|..     |::::.||    ||
Mouse   860 --------------------------TDIVLLLRSSENSVI-----RQLVNHPLTKTGNL----- 888

  Fly   883 DEQPPKSIDDNIMDIE--NTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGISSATGS 945
                |.|...||::.:  |:.|:         |.|.|.::.|...:             :..|.:
Mouse   889 ----PLSKTKNIVNYQMWNSEKS---------TNLTKGETRDVTCH-------------ACETTN 927

  Fly   946 LK----SAVYSYSNGVQTMFDFNAATSHLDKHLQYMHNQAQLSAAAPVDP------KPMDDKRSS 1000
            :|    |:.:.||     :.|.                   ||......|      ||.:::::.
Mouse   928 VKTQTVSSYFRYS-----LMDL-------------------LSKMVVGQPHFVRCIKPNNERQAR 968

  Fly  1001 TPDTG---FASRDTNISLSRRSSQKSSYSPQESFHFPLKGEPLF----SAPPVVMSGGYASLKDE 1058
            ..|..   ...|.|.| |.....::..||.:..|...:|...:.    |..|.|.....|::.::
Mouse   969 KYDKEKVLLQLRCTGI-LETARIRRLGYSHRILFANFIKRYYILCYKSSEEPPVSPDTCAAILEK 1032

  Fly  1059 LGYERFGNGATK---------QMLASASPIKSGVGLNASSGSVYMGSKGYRQRSTSFNESFHPIS 1114
            .|.:.:..|.||         |:........:.:.|..:|...::|::.|::
Mouse  1033 AGLDNWALGKTKVFLKYYHVEQLNLMRKEATNKLVLIQASVRAFLGARRYQE------------- 1084

  Fly  1115 PVLSEPPQRERGVIQRQVRLEQQQPLPRRSASYKP---RSIRART----------------LRRL 1160
              |.:..:....:||...|....:...:.:::.|.   |||||:.                :::.
Mouse  1085 --LQQKRKSSAVIIQSAARRHLLRKHGKETSNVKSAAGRSIRAKDQEFDYKKNFETKRESFVKKQ 1147

  Fly  1161 SYNPM-TLDSSSSSGEEPVKPSLARSECDIRARVAASSNSSLGRRRRA----------GMNRQVQ 1214
            :.|.: |.:|::|:......||..:: ...||...|::..|..||...          |.|:::.
Mouse  1148 TENAVPTNESNTSTPNNKESPSAGKT-APFRAESKATNVESNNRRYHTQKKMSNVYAEGQNQELY 1211

  Fly  1215 SACHDEREVIISPRQMY 1231
            ..  ::....:||||.|
Mouse  1212 IV--EDTWAEVSPRQKY 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	72/287 (25%)
		PTKc_Ack_like	137..398	CDD:270636	73/285 (26%)
		SH3	400..454	CDD:214620	16/102 (16%)
		CRIB	486..525	CDD:238077	10/78 (13%)
Myo3a	NP_680779.3	PKc_like	10..295	CDD:304357	74/279 (27%)
		S_TKc	29..295	CDD:214567	72/275 (26%)
		MYSc	345..1060	CDD:214580	140/866 (16%)
		MYSc_Myo3	360..1048	CDD:276830	136/839 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910