DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and epha4a

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_005171372.1	Gene:	epha4a / 64271	ZFINID:	ZDB-GENE-001207-7	Length:	1034	Species:	Danio rerio

Alignment Length:	371	Identity:	129/371 - (34%)
Similarity:	180/371 - (48%)	Gaps:	47/371 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            |.|..|.:.|.:|.||||.|..| :...|...|.||||.|..........:||.||:||...:|.
Zfish   654 IDASCIKIEKVIGIGEFGEVCSGRLKMPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP 718

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            ||:||.|||.....:|::||.....||...|:.:..|   .|:..|......|.:||:||.....
Zfish   719 NIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR---FTVIQLVGILRGIASGMKYLSDMSY 780

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNV-------NLKLPIAWCAPECINY 314
            :|||||||||||.|....|:||||:||.|....|...|...:       ..|:||.|.|||.|.|
Zfish   781 VHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITY 845

  Fly   315 LRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCW 379
            .:||:|||||::|:.:||:.|||.:|:..::...:::||: ..| ||..|..||...:.||:.||
Zfish   846 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGY-RLPPPMDCPVSLHQLMLDCW 908

  Fly   380 QDDAAKRPRFGEIYDQLPDM--KPEQLK------AVVNCT--EPKKDHLLYRQGDIISVLDRNTG 434
            |.:.|:||:|.:|.:.|..:  .|..||      |..|.|  ||.........|   ||.|
Zfish   909 QKERAERPKFSQIVNMLDKLIRNPNSLKRTGGEIARPNTTLLEPSSPEFTSTLG---SVAD---- 966

  Fly   435 TPFWKGVLSTGK-------TGYFNPSNTVAFLEGLPSSTRDSFSRV 473
               |...::..:       .||..|       |.:...|::..:|:
Zfish   967 ---WLQAINMERYRDNFTAAGYTTP-------EAVVHMTQEDMTRI 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	107/270 (40%)
		PTKc_Ack_like	137..398	CDD:270636	107/268 (40%)
		SH3	400..454	CDD:214620	16/68 (24%)
		CRIB	486..525	CDD:238077
epha4a	XP_005171372.1	EphR_LBD_A4	33..206	CDD:198450
		FN3	332..438	CDD:238020
		FN3	443..534	CDD:238020
		EphA2_TM	554..654	CDD:291255	129/371 (35%)
		PTKc_EphR_A	654..929	CDD:270651	110/279 (39%)
		Pkinase_Tyr	659..925	CDD:285015	107/270 (40%)
		SAM_EPH-A4	959..1029	CDD:188944	11/61 (18%)
		SAM	960..1023	CDD:197735	11/60 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910