DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ack-like and BLK

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:XP_011542126.1 Gene:BLK / 640 HGNCID:1057 Length:531 Species:Homo sapiens


Alignment Length:500 Identity:136/500 - (27%)
Similarity:217/500 - (43%) Gaps:125/500 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PQIDLYEFLTESELQQYYNAVKNELKITNAAQFKYAA--DEDLRFIGLSRPEI----------RR 56
            |.:.::..||.....::.:..|:.:    .|.:.|.|  |.||:.:...:.::          |.
Human    39 PPLVVFNHLTPPPPDEHLDEDKHFV----VALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARS 99

  Fly    57 LRKFYEKHFPHSYLSKI------------------KRLLQAP----GTMVKREEAPGGGS----- 94
            |....|.:.|.::::::                  :|.|.||    |:.:.||.....|:     
Human   100 LVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSV 164

  Fly    95 -QVALDGS------------------------SASACSSLAAKNGASSPSKV--------PNN-- 124
             .|...|.                        |..|.....:|.|.....::        |.|  
Human   165 KDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW 229

  Fly   125 ---KHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMH 186
               :..||..|:.:.::||:|:||.|..|.:.|   .::||||.|....|  :|..||.||.:|.
Human   230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN---NMKVAIKTLKEGTM--SPEAFLGEANVMK 289

  Fly   187 SIEHENIVRLYGVVLATDSLMLVTE---------------------LAHLR-----SLLECLK-D 224
            :::||.:||||.|| ..:.:.:|||                     |:..|     .||:.|| |
Human   290 ALQHERLVRLYAVV-TKEPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTD 353

  Fly   225 SGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGK 289
            .|.|   |::|.|.:.:.||..||.|:|:...|||||.|.||||......||:||||:|.  :..
Human   354 EGSR---LSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARI--IDS 413

  Fly   290 DYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAID 354
            :|   ......|.||.|.|||.|::..||..:|||:|||.|.|:.:||..|:..::..:::..::
Human   414 EY---TAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLE 475

  Fly   355 APNYQRLEQPDCCPSEYYT-LMMKCWQDDAAKRPRFGEIYDQLPD 398
            . .| |:.:||.||.|.|. ::.:||:....:||.|..:...|.|
Human   476 R-GY-RMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLED 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938 13/72 (18%)
STYKc 133..396 CDD:214568 101/290 (35%)
PTKc_Ack_like 137..398 CDD:270636 102/288 (35%)
SH3 400..454 CDD:214620
CRIB 486..525 CDD:238077
BLKXP_011542126.1 SH3_Blk 62..115 CDD:212942 10/56 (18%)
SH2_Src_Blk 120..219 CDD:198234 14/98 (14%)
PKc_like 233..522 CDD:304357 105/301 (35%)
Pkinase_Tyr 241..516 CDD:285015 101/290 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D539311at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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