DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and RET

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens

Alignment Length:	382	Identity:	116/382 - (30%)
Similarity:	174/382 - (45%)	Gaps:	55/382 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 FPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIP 129
            ||.||.|          :..:|.......:||::|....                 :.:.|...|
Human   683 FPVSYSS----------SGARRPSLDSMENQVSVDAFKI-----------------LEDPKWEFP 720

  Fly   130 ADSISVNKQLGTGEFGIVQQGVWSNGNER---IQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            ..::.:.|.||.||||.|.:....:...|   ..||:|.|......|...:.|.|..::..:.|.
Human   721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 785

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDS-----------GLRVS---------FLTIPT 236
            ::::|||.......|:|:.|.|...||...|::|           |.|.|         .||:..
Human   786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGD 850

  Fly   237 LCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLK 301
            |..||.||..||:||.:.:|:|||||||||||....|:|||||||||.:.....|.|.:..   :
Human   851 LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG---R 912

  Fly   302 LPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDC 366
            :|:.|.|.|.:....:|..||||:|||.|||:.:.|..|:..:...::...:...:  |:|:||.
Human   913 IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH--RMERPDN 975

  Fly   367 CPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQG 423
            |..|.|.||::||:.:..|||.|.:|...|..|..::...:........|.|:|..|
Human   976 CSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDG 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	116/382 (30%)
		STYKc	133..396	CDD:214568	99/285 (35%)
		PTKc_Ack_like	137..398	CDD:270636	100/283 (35%)
		SH3	400..454	CDD:214620	4/24 (17%)
		CRIB	486..525	CDD:238077
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	101/293 (34%)
		Pkinase_Tyr	724..1005	CDD:285015	99/285 (35%)
		Inhibitors binding	805..807		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910