DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and PTK6

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens

Alignment Length:	436	Identity:	128/436 - (29%)
Similarity:	197/436 - (45%)	Gaps:	88/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FKYAADEDLRFIGLSRPEIRRLRKFY--------------EKHFPHSYL---------------- 70
            ||...||:|.|.......:.|..:.:              :.:.||:||
Human    19 FKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCI 83

  Fly    71 --SKIKRLLQAPGT-----MVKREEAPG---------------------GGSQVALD-------- 99
              |:..|.|||.|.     :::..|.|.                     .|.::.|:
Human    84 SRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSL 148

  Fly   100 --------GSSASACSSLAAKNGASSPSKVPN-NKHIIPADSISVNKQLGTGEFGIVQQGVWSNG 155
                    ..|.|....|||......|..:|: :....|.:..::.::||:|.||.|.:|:|
Human   149 PELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLW--- 210

  Fly   156 NERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLE 220
            .:|:|||||.:.|:.:....| ...|...|..:.|::|:.||.||...|.:.::|||....||||
Human   211 KDRVQVAIKVISRDNLLHQQM-LQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLE 274

  Fly   221 CLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRAL 285
            .|:||..:|  |.:..|.:.|.|:..||.|||.:..||||||||||||......|:.||||:|.
Human   275 LLRDSDEKV--LPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARL- 336

  Fly   286 GVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQIL 350
             :.:|.|.::   :..:|..|.|||.::...::..||||:||:.|.||||.|..|:..::..:..
Human   337 -IKEDVYLSH---DHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAF 397

  Fly   351 EAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            ..:|| .| |:..|..||...:.||:.||..|..:||.|..:.::|
Human   398 LRVDA-GY-RMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	7/42 (17%)
		STYKc	133..396	CDD:214568	98/262 (37%)
		PTKc_Ack_like	137..398	CDD:270636	99/260 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	11/49 (22%)
		SH2_PTK6_Brk	75..174	CDD:198221	15/98 (15%)
		Linker	171..190		3/18 (17%)
		PTKc_Srm_Brk	184..444	CDD:133248	100/271 (37%)
		STYKc	192..441	CDD:214568	98/261 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010