Protein Alignment Ack-like and tnk1

DIOPT Version :10

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: NP_001073486.3
• Gene: tnk1 / 565029
• ZFINID: ZDB-GENE-030131-7427
• Length: 733
• Species: Danio rerio
• Alignment Length: 640
• Identity: 193/640 - (30%)
• Similarity: 299/640 - (46%)
• Gaps: 120/640 - (18%)

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            ||:.|.:.:|:::|..:::.|.:|......|..:.||..||:|:|..|||.:..:::
Zfish     9 LYQLLADVQLERFYLRMRDGLNVTRMEHLSYVKEADLEQIGISKPGQRRLWEAVKRY-------- 65

  Fly    73 IKRLLQAPGTMVK--REEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISV 135
             |..::|...|||  ...||.|..|....||......:|..               :|....:..
Zfish    66 -KTNMRARSWMVKATNGRAPEGNDQSNAAGSGQGPVRALTC---------------LIQDRELLF 114

  Fly   136 NKQLGTGEFGIVQQGVWSNGNERI-QVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGV 199
            ..:||:|.||:|::..|.....|: .||:|.| |........:||:|...|.|::|.||:.||||
Zfish   115 GDRLGSGSFGVVRKAEWHTPTGRVLPVAVKTL-RSGQVDLVSDFLQEVTSMQSLDHPNIIHLYGV 178

  Fly   200 VLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            || |..|.:|||||.|.||.:.|:   ||.....:..|..|:.||..||.|||.:|.||||||||
Zfish   179 VL-THPLKMVTELAPLGSLYDTLR---LRHGEYPLSRLWLFSTQIAAGMEYLESRRFIHRDLAAR 239

  Fly   265 NILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVC 329
            |:|:.::::|||.||||.|.|. .:|:|  ....:.::|.||||||.:....|::|||||.|||.
Zfish   240 NVLLAAREQVKIGDFGLMRGLD-DRDHY--IMTAHRRIPFAWCAPESLRTGSFSHASDVWMFGVT 301

  Fly   330 LWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYD 394
            |||||:|..:||..|:|.|||..::... :|||:|..||.|.|.:|.|||..::.:||.|.::..
Zfish   302 LWEMFTYCEEPWLGLSGRQILYRVEREG-ERLERPPDCPQELYAVMRKCWACNSTERPTFAQLTT 365

  Fly   395 QLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV-LSTGKTGYFNPSNTVAF 458
            .:.:.:|.::::|.:..||::  |..:..|:::|:|.......|||. ..|...|:|.|:.|...
Zfish   366 MVSEAQPMEVRSVKDIAEPRR--LSLQANDLVTVIDHGLDMCEWKGQNQRTLSVGWFPPALTAPA 428

  Fly   459 LEGL--------------------------PSSTRDSFSRVSDHR-----ISKRKLRTEM----- 487
            |..:                          |..:|.:..|:.|:|     ::|.|..:.:
Zfish   429 LTAVVPASGPTLISSPVRGSLHHTGHGDTDPGRSRGTPERIDDNRRWRVPLAKEKEGSNLKKMAG 493

  Fly   488 --------ISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLL 544
                    :..||:  |..| ||::.|...|       |..|.....::...:...|....|
Zfish   494 MSRSLESVLGGPQD--KGRG-VGVNAAQRSD-------QRRNMQNNNVIQDPRRFSDAVVIP--- 545

  Fly   545 PPTPTSPD--SLQ-------------TASGYFPEGANSGGAMGTSMNPTFIPSAE 584
            ||.|..|:  |::             ..||:.|:         |...|.|.|..:
Zfish   546 PPRPPPPNIKSIKPQMMMMFLDRRAANPSGWSPQ---------TQAQPQFQPQQQ 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	17/56 (30%)
		PTKc_Ack_like	137..398	CDD:270636	115/261 (44%)
		SH3	400..454	CDD:214620	15/54 (28%)
		CRIB	486..525	CDD:238077	10/51 (20%)
tnk1	NP_001073486.3	None