DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and aatkb

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_021328264.1	Gene:	aatkb / 555739	ZFINID:	ZDB-GENE-100812-6	Length:	1657	Species:	Danio rerio

Alignment Length:	1471	Identity:	287/1471 - (19%)
Similarity:	455/1471 - (30%)	Gaps:	449/1471 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 KQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVL 201
            |::|.|.||.|..|...:|....||.:|.|.......:.|.||:||....|::|..:|:......
Zfish   137 KEIGNGWFGKVLLGEVHSGLSSTQVVVKELKASASVQDQMHFLEEARPYRSLQHPALVQCLAQCT 201

  Fly   202 ATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCE-FALQICNGMRYLEQKRLIHRDLAARN 265
            .....::|.|...|..:...|.......|.:..|.|.: .|.:|.:|:.:|.:....|||||.||
Zfish   202 EVTPYLVVMEFCPLGDVKGYLCSCRTADSLIPDPLLLQRMACEITSGLLHLHKNNFTHRDLALRN 266

  Fly   266 ILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLK---LPIAWCAPECINYLR-------FTNA 320
            .|:.|..||||.|:|||.      :.||.::.|...   :|:.|.|||.::.:.       .|..
Zfish   267 CLLTSDIKVKIGDYGLSH------NKYKDDYFVTSDQTWVPLRWIAPELVDEVHGNLLVVDQTKE 325

  Fly   321 SDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDC---CPSEYYTLMMKCW-QD 381
            |::|:.||.:||:|..|.||:...:..|:|.........:|.:|..   ....:|.:|..|| |.
Zfish   326 SNIWSLGVTIWELFELGNQPYRHYSDRQVLSYAVKDQQLKLSKPILKYPLADRWYEVMQFCWLQP 390

  Fly   382 DAAKRPRFGEIYDQLP-------------------DMKPEQLKAVVNCTE--------------- 412
            |  :||...|::..|.                   .|:|...:|.::...
Zfish   391 D--QRPNAEEVHLLLSYLCAKGASEAEEDFERRWNSMRPNTSQANIHGAGALAIDMPMSSTTSSF 453

  Fly   413 ------PKKDHLLYRQG-DIISVLDRNTGTPF-WKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDS 469
                  |..|......| ||::|.:.:.|..| :|...:..:..|.:.|.|....:|.|
Zfish   454 PLLEQFPSGDGYHSESGDDILTVTETSHGLNFEYKWEQARAEQHYHSSSTTGTLGQGNP------ 512

  Fly   470 FSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTP---- 530
                          ..:.:..|....  .|...:||..      ||.|.:| :.|||:.||
Zfish   513 --------------HCQEVYYPPGGI--VGGCAVDGLA------LGVSPSY-YEPKQLHTPGVVP 554

  Fly   531 ----YKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIA 591
                :.||...|....:..|..::.|...|...|.||...|.|:
Zfish   555 VLSAHSPSVSNEYYIRIEEPVQSNIDMNFTMCAYSPEFGGSNGS--------------------- 598

  Fly   592 TNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYHEISD 656
                    |.:||                    |..|:.::..    |.::..:....|.|
Zfish   599 --------FLTGS--------------------GDSGECMNCP----PEAKPDIYWSAEVH---- 627

  Fly   657 DEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDTNGNK 721
                                             ||..:|..::......|...||
Zfish   628 ---------------------------------KSGAYDSDSSPAMSLTMEPLLG---------- 649

  Fly   722 HGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPVIHSPKRKFSFR 786
            ||..|     :...||..  :|.||.....:......::..|.||   .|.|..:.......|.|
Zfish   650 HGSPL-----RAWESGHY--VSYKDRDGGYYFEPSPPKVMGRYMI---RDSTETLQESWGSRSLR 704

  Fly   787 FPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKK-------KNFTEELQSIPDIQRFRSLSEI 844
                  ...|:....||.|.|..:|..|.|.|:.:.       ||.|.....:....|.......
Zfish   705 ------QALGELEDPLGISPSLGSPPQGYADPYLESIQGSIIGKNVTGGYYDMMGSLRKTMPGGH 763

  Fly   845 KNSTDLRV--PIF--------DKESSDFLFQKSRE-ILSRPLNLERECGDEQPPKSIDDNIMDIE 898
            ...||:..  .:|        |:|...|:.::.|. ..|.|.|.......::....|.|:..|..
Zfish   764 SVCTDIASGGAVFVGRDDSESDEEEDIFVERRGRSWSASNPPNTNPRTLRQRQGSCIQDSYADFH 828

  Fly   899 NTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGISSATGSLKSAVYSYSNGVQTMFDF 963
            .|:..                   |.:.|..|...:|...::.....|::.:.|
Zfish   829 YTMPM-------------------TDIEDTWPEQQTLSYHMTKPVDYLEAPIKS----------- 863

  Fly   964 NAATSHLDKHL---------QYMHNQAQLSAAAPVDPKPMDDKRSST----PDTGFASRDTNISL 1015
            |....| .:|:         .|:| .......|.|.|.|.....||:    |.||...|  |..:
Zfish   864 NTCLVH-GRHVPSNPSPECNSYIH-MCHEPREAEVYPVPCCQALSSSHFVDPLTGTLVR--NCFM 924

  Fly  1016 SRRSSQKSSYSPQESFHFPLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIK 1080
            ......|:...|....|.||             |.|:...|.|...|    || ||...|...:.
Zfish   925 IDCIPGKTMTLPNRDQHLPL-------------SAGHIISKIEASRE----GA-KQFDISEQFVD 971

  Fly  1081 SGVGLNASSGSVYMGSKGYRQRSTSFNE--SFHPISPVLSEPPQRERGVIQRQVRLEQQQPLPRR 1143
            :.|           |....:|..|...:  :..|.:.:::..||.|:.      ..|..:|.|..
Zfish   972 TAV-----------GETNLKQEKTLHQDISTADPKTEIIAIYPQLEKS------PAELSKPEPES 1019

  Fly  1144 SASYKPRSIRARTLRRLSYNPMTLDSSSSSGEEPVKPSLAR-SEC------DIRARVAAS----- 1196
            ..|                  .|.||....|...:  ||.. .:|      |:.:.:...
Zfish  1020 ELS------------------KTADSGMDRGHSSI--SLVEIDDCSDDDITDVTSGIFGDFAIEV 1064

  Fly  1197 ------SNSSLGRRRRAGMNRQVQS------ACHDEREVIISPRQMYGSNSSIKSAPHYNIGGQR 1249
                  |.:....:::.|....:.|      ||..|   .:||..::.|:|
Zfish  1065 ETVDYPSPAFKSLQKQVGTPDSMDSIDIPSTACSSE---TLSPASIHPSSS-------------- 1112

  Fly  1250 RSFHRGGPGVMGGGYE-------QFQYDER---------IYDFGGRGPGNNY-------NMAQAS 1291
                   |..:..||:       :|...|.         |...|....|.::       ...:..
Zfish  1113 -------PKTVDSGYDTENNESPEFVLKEPHEVQDSKTFIQPLGKVTSGTSFVSEDQEITTTECE 1170

  Fly  1292 YLSSSQKPSYLLNGSELPGSGSGSSSAASSAVQATYRPGAGTSVQRPMSGGAALHEFDISRLTGK 1356
            .|......:..|..||   |..|...|.|.              :.|....|...::|    .||
Zfish  1171 KLEGDFYTAVALTASE---SSDGELKALSD--------------KTPYRDSAYFSDYD----AGK 1214

  Fly  1357 SPTSTNFVGSSPEELKQRQLSVGSL-----QTPNNKVAKPQRPTEFHWPEKIHASAVKQHEMHWR 1416
            ...|...:    .||:.::...|.:     |.|      ||:.|:.  .|.:..|..|..::...
Zfish  1215 DKESEEDI----NELEDQKDRPGEIIYKEEQLP------PQKETDV--DEYLMPSTKKSEKIPEL 1267

  Fly  1417 QVHQQQSLPTASIITAAVGGAVSARRSSDSSSSSSTESGDE 1457
            ..|...:||:.:..:.:|.|.:.:...|.....|:.:|..|
Zfish  1268 SDHSISNLPSMTDESLSVCGTICSVSLSPLKDVSTIKSSFE 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	80/273 (29%)
		PTKc_Ack_like	137..398	CDD:270636	81/294 (28%)
		SH3	400..454	CDD:214620	12/76 (16%)
		CRIB	486..525	CDD:238077	8/38 (21%)
aatkb	XP_021328264.1	PKc_like	135..405	CDD:328722	81/275 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910