DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and map3k7

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_009292938.1	Gene:	map3k7 / 553788	ZFINID:	ZDB-GENE-041001-135	Length:	578	Species:	Danio rerio

Alignment Length:	512	Identity:	131/512 - (25%)
Similarity:	202/512 - (39%)	Gaps:	117/512 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLY 197
            |.|.:.:|.|.||:|.:..|...:    ||||.:   ..:|....|:.|...:..::|.|||:||
Zfish    25 IEVEEVVGRGAFGVVCKAKWKGRD----VAIKTI---ESESEKNAFIVELRQLSRVDHPNIVKLY 82

  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYL---EQKRLIHR 259
            |  ...:.:.||.|.|...||...|..:. .:...|......:.||...|:.||   :.|.||||
Zfish    83 G--SCNNPVCLVMEYAEGGSLYNVLHGAE-PLPHYTASHAMSWCLQCSQGVSYLHGMKPKALIHR 144

  Fly   260 DLAARNILVFSKDKV-KISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDV 323
            ||...|:|:.:...| ||.|||.:..:       :|:. .|.|...||.|||......::...||
Zfish   145 DLKPPNLLLVAGGTVLKICDFGTACDI-------QTHM-TNNKGSAAWMAPEVFEGSNYSEKCDV 201

  Fly   324 WAFGVCLWEMFSYGFQPWAALTG--LQILEAIDAPNYQRLEQPDC---CPSEYYTLMMKCWQDDA 383
            :::|:.|||:.:.. :|:..:.|  .:|:.|:     .|..:|..   .|....:||.:||..|.
Zfish   202 FSWGIILWEVITRR-KPFDEIGGPAFRIMWAV-----HRGTRPPLIKNLPKAIESLMTRCWSKDP 260

  Fly   384 AKRPRFGEIYDQLPDM------KPEQLK--------AVVNCTEPKKDHLLY----RQGDIISVLD 430
            ::||...||...:..:      ..|.||        ...|.......||.|    .:.||.....
Zfish   261 SQRPSMEEIVKIMSHLMGYFPGSEEPLKYPYQYSDEGQSNSATSTGSHLDYTCTSNKNDINMEHT 325

  Fly   431 RNTGT------PFW-KGV----LSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHR-----IS 479
            .:.|:      |:. ||:    ||.|.:           :|.||.  |..|...||.:     :|
Zfish   326 NSPGSNDTIKFPYKPKGISGQSLSRGSS-----------VESLPG--RSHFQPSSDSKRMSVELS 377

  Fly   480 KRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVT----PYKPSEDIEQT 540
            :.:.|....|..:..:|. ||  ...|:.|.|.         .:||.|||    |:: ...::..
Zfish   378 ELEPRLPFASPARPQYKR-GH--RKTASHGTIL---------DIPKIIVTATCEPHR-RRSVQDL 429

  Fly   541 PLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSS 597
            |.:  .|..|.||...:               .|.:|:|   ...||....|||..:
Zfish   430 PAI--GTDASQDSRNNS---------------RSSSPSF---RMITPDRTDTNGSDN 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	80/271 (30%)
		PTKc_Ack_like	137..398	CDD:270636	78/269 (29%)
		SH3	400..454	CDD:214620	16/76 (21%)
		CRIB	486..525	CDD:238077	7/38 (18%)
map3k7	XP_009292938.1	TyrKc	25..273	CDD:197581	80/271 (30%)
map3k7	XP_009292938.1	STKc_TAK1	31..281	CDD:270960	78/273 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910