DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and zap70

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001018425.1	Gene:	zap70 / 553615	ZFINID:	ZDB-GENE-050522-257	Length:	604	Species:	Danio rerio

Alignment Length:	330	Identity:	120/330 - (36%)
Similarity:	181/330 - (54%)	Gaps:	27/330 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GSSASACSSLAAKNGASSPSKVPNNKH----IIPADSISVNK-QLGTGEFGIVQQGVWSNGNERI 159
            |:..|..|.....:|.:||...||...    .|..|.:.::: :||:|.||.|::||:...:::|
Zfish   287 GAEGSRPSLPMDHDGFTSPYDDPNELKKKTLFIKRDKLMIDEVELGSGNFGCVKKGVFKMESKQI 351

  Fly   160 QVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELA---HLRSLLEC 221
            .||||.|..|..:|...|.::||.|||.:....|||:.|:..| ::||||.|:|   .|...|..
Zfish   352 DVAIKVLKNENEKSVRDEMMREAEIMHQLSDPFIVRMIGLCEA-EALMLVMEMAPAGPLNKFLSG 415

  Fly   222 LKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALG 286
            .||.      :|...:.....|:..||:|||.:..:||||||||:|:.::...||||||||:|||
Zfish   416 KKDQ------ITTENIVMLMHQVSMGMKYLEGRNFVHRDLAARNVLLVNQQYAKISDFGLSKALG 474

  Fly   287 VGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILE 351
            ...:|||.  ....|.|:.|.|||||::.:|::.||||:||:.:||.||:|.:|:..:.|.:::.
Zfish   475 ADDNYYKA--RTGGKWPLKWYAPECIHFHKFSSKSDVWSFGITMWEAFSFGGKPYKKMKGPEVIT 537

  Fly   352 AIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI-------YDQLPDMKPEQLKAVVN 409
            .|:..:  ||:.|..||...|.||.:||.....:|..|.::       |..:....|:.|| ..|
Zfish   538 YIEGGS--RLDCPAACPEAMYELMKECWTYKHEERLNFAKVEEKMRTFYYSIAKKIPDYLK-TEN 599

  Fly   410 CTEPK 414
            .|.||
Zfish   600 GTPPK 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	103/273 (38%)
		PTKc_Ack_like	137..398	CDD:270636	103/271 (38%)
		SH3	400..454	CDD:214620	7/15 (47%)
		CRIB	486..525	CDD:238077
zap70	NP_001018425.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191
		SH2_C-SH2_Zap70	152..256	CDD:198265
		PTKc_Zap-70	320..588	CDD:270686	104/278 (37%)
		Pkinase_Tyr	330..580	CDD:285015	102/260 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910