DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and hck

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001015722.1	Gene:	hck / 548439	XenbaseID:	XB-GENE-6048191	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	303	Identity:	115/303 - (37%)
Similarity:	165/303 - (54%)	Gaps:	20/303 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GSSASACSSLAAKNGASSPSKVPNNKHI--IPADSISVNKQLGTGEFGIVQQGVW-SNGNERIQV 161
            |..:..|..|........|.| |..|..  ||.:|:|:.|:||||:||    .|| :..|...:|
Frog   199 GKMSGLCQCLTVPCQTLRPEK-PWEKDAWEIPRESLSLQKKLGTGQFG----DVWLATYNGHTEV 258

  Fly   162 AIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKD-S 225
            |:|.:....|  :|..||:||.:|.|::||.:|||:.||...:.:.:|||..|..|||:.||. .
Frog   259 AVKTMKAGSM--SPAAFLEEANLMKSLQHERLVRLHAVVTQGEPIYIVTEYMHKGSLLDFLKSPE 321

  Fly   226 GLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKD 290
            |.|   ..:..|.:|..||..||.::||:..|||||.|.|.||......||:||||:|.: ...:
Frog   322 GSR---QPVTQLIDFCAQIAEGMWFIEQRNYIHRDLRAANCLVSETLLCKIADFGLARVI-EDSE 382

  Fly   291 YYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDA 355
            |   ......|.||.|.:||..||..||..||:|:|||.|.|:.:||..|:..::..:::.|::.
Frog   383 Y---TAREGSKFPIKWTSPEAANYGSFTIKSDIWSFGVLLSEIMTYGRSPYPGMSNSEVMAALER 444

  Fly   356 PNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
             .| |:..|..||:|.|.:|::|||.|..|||.|..:.:.|.|
Frog   445 -GY-RMPCPGTCPTELYGIMLQCWQQDPHKRPTFEYLQNILED 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	103/264 (39%)
		PTKc_Ack_like	137..398	CDD:270636	103/262 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
hck	NP_001015722.1	SH3	57..112	CDD:388381
		SH2_Src_family	115..211	CDD:199827	3/11 (27%)
		PTKc_Src_like	237..484	CDD:270630	102/261 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010