Protein Alignment Ack-like and MAP3K20

DIOPT Version :9

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Alignment Length: 1156
• Identity: 230/1156 - (19%)
• Similarity: 374/1156 - (32%)
• Gaps: 466/1156 - (40%)

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            |..|.:...:..|.|.||.|.:..|.:.::  :||:|.|         ::..|||.|:..:.|.|
Human    11 IKFDDLQFFENCGGGSFGSVYRAKWISQDK--EVAVKKL---------LKIEKEAEILSVLSHRN 64

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQK--- 254
            |::.|||:|...:..:|||.|.|.||.:.:..:  |...:.:..:..:|..:..||.||..:
Human    65 IIQFYGVILEPPNYGIVTEYASLGSLYDYINSN--RSEEMDMDHIMTWATDVAKGMHYLHMEAPV 127

  Fly   255 RLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            ::|||||.:||:::.:...:||.|||.||       ::....:::|.....|.|||.|..|..:.
Human   128 KVIHRDLKSRNVVIAADGVLKICDFGASR-------FHNHTTHMSLVGTFPWMAPEVIQSLPVSE 185

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            ..|.:::||.||||.:... |:..|.|||:...:...| :||..|..||..:..|:.:||:.||.
Human   186 TCDTYSYGVVLWEMLTREV-PFKGLEGLQVAWLVVEKN-ERLTIPSSCPRSFAELLHQCWEADAK 248

  Fly   385 KRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGY 449
            |||.|.:|...|..|..:      .....|.:..|:.:.:             |:..:.
Human   249 KRPSFKQIISILESMSND------TSLPDKCNSFLHNKAE-------------WRCEIE------ 288

  Fly   450 FNPSNTVAFLEGLPSSTRD-SFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAF 513
                   |.||.|....|| ||   .:..:.:|:.|.:|..:
Human   289 -------ATLERLKKLERDLSF---KEQELKERERRLKMWEQ----------------------- 320

  Fly   514 LGSSQNYNHVPKQIVTPYKPSEDI-----EQTPLLLPPTPTSPDSLQTASGY---FPEGANSG-- 568
                    .:.:|..||..||.:|     :.....:.......||....|.|   |.|...:|
Human   321 --------KLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKR 377

  Fly   569 ------------GAMGTSMNPTFIPSAE----------HTPKLIATNGQSSFDFASGSTNPFFPN 611
                        |.:.......|..:.|          |.|.||..:|..             |.
Human   378 LLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGE-------------PE 429

  Fly   612 RGDD-----ELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYHEISDDEIA---ADKLDFGP 668
            ..::     ||.||.|.....|.   .:..|:           .|.|:..||||   ...:.|..
Human   430 ENEEKIVNLELVFGFHLKPGTGP---QDCKWK-----------MYMEMDGDEIAITYIKDVTFNT 480

  Fly   669 SLLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKK 733
            :|.|.                            ||.:|:
Human   481 NLPDA----------------------------EILKMT-------------------------- 491

  Fly   734 KSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDK 798
                  ||..|.::.|    :.||...:....:...||    :.:||.
Human   492 ------KPPFVMEKWI----VGIAKSQTVECTVTYESD----VRTPKS----------------- 525

  Fly   799 SGGLGTSGSAHTPTHGNASPFPKKKNFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFL 863
                                       |:.:.||
Human   526 ---------------------------TKHVHSI------------------------------- 532

  Fly   864 FQKSREILSRPLNLERECGDEQPPKSIDDNIMDIENTLKALNLDFMHTYTELD-----KSDSN-- 921
             |.||   ::|                       ::.:||:.|.....:|..|     :|||:
Human   533 -QWSR---TKP-----------------------QDEVKAVQLAIQTLFTNSDGNPGSRSDSSAD 570

  Fly   922 ----DTILNDQLPHMASLDDGISSATGSLKSAVYSYSNGVQTMFDFNAATSHLDKHLQYMHNQAQ 982
                ||:...|:....||..  |.:...|.|..:|:.:|..:   :.||.......::|.    |
Human   571 CQWLDTLRMRQIASNTSLQR--SQSNPILGSPFFSHFDGQDS---YAAAVRRPQVPIKYQ----Q 626

  Fly   983 LSAAAPVDPKPMDDKRSSTP-----------------DTGFASRDTNISLSRRSSQKSSYSPQES 1030
            ::        |::..|||:|                 |:||:|.:|:     .||::..||.:..
Human   627 IT--------PVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTD-----TSSERGRYSDRSR 678

  Fly  1031 FHFPLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIKSGVGLNASSGSVYMG 1095
                                           .::|.|:              :.||:|....|.|
Human   679 -------------------------------NKYGRGS--------------ISLNSSPRGRYSG 698

  Fly  1096 SKGYRQRSTSFNESFHPISPVLSEPPQRER--GVIQRQVRLEQQQPLPRRSASYK--PRSI-RAR 1155
            ..   |.||                |.|.|  |   :..|:.|....|.:|..:|  ||.: :..
Human   699 KS---QHST----------------PSRGRYPG---KFYRVSQSALNPHQSPDFKRSPRDLHQPN 741

  Fly  1156 TLRRLSYNPMT------LDSSSSSG--------EEPVKPSLARSECDIRAR 1192
            |:..:..:|.|      .||..|.|        ::|.:||.|::..: |||
Human   742 TIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKE-RAR 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	83/265 (31%)
		PTKc_Ack_like	137..398	CDD:270636	84/263 (32%)
		SH3	400..454	CDD:214620	3/53 (6%)
		CRIB	486..525	CDD:238077	1/38 (3%)
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	84/262 (32%)
		STYKc	23..260	CDD:214568	83/258 (32%)
		Leucine-zipper	287..308		8/36 (22%)
		SAM_MLTK	338..408	CDD:188928	10/69 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800		44/213 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910