DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and src

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_017953215.1	Gene:	src / 496893	XenbaseID:	XB-GENE-489820	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	499	Identity:	147/499 - (29%)
Similarity:	213/499 - (42%)	Gaps:	133/499 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRR--------LRKFYEKHF 65
            ||..||::|                   .:...|.|:.:..:||::|.        |......:.
Frog    94 YESRTETDL-------------------SFKKGERLQIVNNTRPDMREGDWWLARSLSSGQTGYI 139

  Fly    66 PHS-------------YLSKIKR--------LLQAP-GTMVKREEAPGGGSQV------------ 96
            |.:             ||.||.|        .|:.| ||.:.||.....|:..
Frog   140 PSNYVAPSDSIQAEEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSDYDANRGL 204

  Fly    97 --------ALDG-----SSASACSSLA------AKNG--------ASSPSKVPNNKHI------I 128
                    .||.     :|.:..|||.      :|:.        ...|:..|..:.:      |
Frog   205 NVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSKDAWEI 269

  Fly   129 PADSISVNKQLGTGEFGIVQQGV----WSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIE 189
            |.||:.:..:||.|.||.|..||    | ||..|  ||||.|....|  :|..||:||.:|..:.
Frog   270 PRDSLRLELKLGQGCFGEVWMGVSVGTW-NGTTR--VAIKTLKPGTM--SPEAFLQEAQVMKKLR 329

  Fly   190 HENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQK 254
            ||.:|:||.|| :.:.:.:|||.....|||:.||  |....:|.:|.|.:.|.||.:||.|:|:.
Frog   330 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLK--GEMGRYLRLPQLVDMAAQIASGMAYVERM 391

  Fly   255 RLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            ..:||||.|.||||......|::||||:|.: ...:|   ......|.||.|.|||...|.|||.
Frog   392 NYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGRFTI 452

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            .||||:||:.|.|:.:.|..|:..:...::|:.::. .| |:..|..||...:.||.:||:.|..
Frog   453 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GY-RMPCPPDCPESLHDLMCQCWRKDPE 515

  Fly   385 KRPRFGEIYDQLPDMKPEQLKAVV----NCTEPKKDHLLYRQGD 424
            :||.|            |.|:|.:    ..|||:     |:.||
Frog   516 ERPTF------------EYLQAFLEDYFTATEPQ-----YQPGD 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	11/63 (17%)
		STYKc	133..396	CDD:214568	101/266 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/264 (38%)
		SH3	400..454	CDD:214620	9/29 (31%)
		CRIB	486..525	CDD:238077
src	XP_017953215.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010