DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and NTRK3

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens

Alignment Length:	393	Identity:	121/393 - (30%)
Similarity:	176/393 - (44%)	Gaps:	95/393 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ADEDLRFIGLSR-PEIRR---LRKFYEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDG 100
            |..|...||::| |.|..   .|:.:..|.|.:|:..|||    ...::|||...|...:|.|
Human   496 AGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKR----RDIVLKRELGEGAFGKVFL-- 554

  Fly   101 SSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKC 165
               :.|.:|       ||:|                                    :::.||:|.
Human   555 ---AECYNL-------SPTK------------------------------------DKMLVAVKA 573

  Fly   166 LCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVS 230
            | ::...:...:|.:||.::.:::||:||:.|||....|.|::|.|......|.:.|:..|....
Human   574 L-KDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAM 637

  Fly   231 FLT------------IPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSR 283
            .|.            :..:...|.||.:||.||..:..:|||||.||.||.:...|||.|||:||
Human   638 ILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR 702

  Fly   284 ALGVGKDYY------KTNFNV-----------------NLKLPIAWCAPECINYLRFTNASDVWA 325
            .: ...|||      |..|:|                 :..|||.|..||.|.|.:||..||||:
Human   703 DV-YSTDYYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWS 766

  Fly   326 FGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFG 390
            |||.|||:|:||.|||..|:..:::|.|.....  ||:|..||.|.|.:|:.|||.:..:|....
Human   767 FGVILWEIFTYGKQPWFQLSNTEVIECITQGRV--LERPRVCPKEVYDVMLGCWQREPQQRLNIK 829

  Fly   391 EIY 393
            |||
Human   830 EIY 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	8/28 (29%)
		STYKc	133..396	CDD:214568	96/296 (32%)
		PTKc_Ack_like	137..398	CDD:270636	96/292 (33%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..151	CDD:275378
		leucine-rich repeat	152..164	CDD:275378
		TPKR_C2	163..208	CDD:293525
		Ig_TrkABC_d4	211..301	CDD:143173
		IG_like	218..301	CDD:214653
		Ig_TrKABC_d5	319..396	CDD:143172
		PTKc_TrkC	532..843	CDD:270676	110/357 (31%)
		TyrKc	538..835	CDD:197581	107/347 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910