DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Abl

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster

Alignment Length:	1633	Identity:	332/1633 - (20%)
Similarity:	523/1633 - (32%)	Gaps:	623/1633 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSN-GNERIQVAIKCLCRERMQSNPMEFLKEA 182
            |..|:...|...| |.:..:||.|::|.|.:.||.. ||   .||:|.|..:.|...  :||:||
  Fly   376 SPEPDEWEICRTD-IMMKHKLGGGQYGEVYEAVWKRYGN---TVAVKTLKEDTMALK--DFLEEA 434

  Fly   183 AIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNG 247
            |||..::|.|:|:|.||........::||.....:||:.|:.:|...  |....|...|.||.:|
  Fly   435 AIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRET--LDAVALLYMATQIASG 497

  Fly   248 MRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECI 312
            |.|||.:..|||||||||.||.....||::||||:|.:  ..|.|..  :...|.||.|.|||.:
  Fly   498 MSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM--RDDTYTA--HAGAKFPIKWTAPEGL 558

  Fly   313 NYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMK 377
            .|.:|:..||||||||.|||:.:||..|:.|:....:...:| ..| |:|:|..||.|.|.||.:
  Fly   559 AYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLD-KGY-RMERPPGCPPEVYDLMRQ 621

  Fly   378 CWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV- 441
            |||.||..||.|..|:..|..|..|.     :.||..:..|      ..:....::..|...||
  Fly   622 CWQWDATDRPTFKSIHHALEHMFQES-----SITEAVEKQL------NANATSASSSAPSTSGVA 675

  Fly   442 ------LSTGKTGYFNPSNTVAFL--------EGLP----------------------------- 463
                  .:|..:|..:.|:..|.|        :|||
  Fly   676 TGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGST 740

  Fly   464 --------------------------------------SSTRDSFSRVSD--------------- 475
                                                  ||:|||..|..|
  Fly   741 STKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTN 805

  Fly   476 --HRISKRKLRTEMIS---KPQNDFKHTGHVGID------------------------------- 504
              |::......::.:|   |.|....||..:...
  Fly   806 GIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQ 870

  Fly   505 ----------GATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTA-- 557
                      .:...||.|.|.:::.|.:.::.        |.|..|...|.|..:.|||:.:
  Fly   871 QYSIKKSSSCSSFLYDILFRGLARDINSLTQRY--------DSETDPAADPDTDATGDSLEQSLS 927

  Fly   558 -------SGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDD 615
                   :.......:|||. |..:.|.  .|.:|          |||...:|:  |...||
  Fly   928 QVIAAPVTNKMQHSLHSGGG-GGGIGPR--SSQQH----------SSFKRPTGT--PVMGNR--- 974

  Fly   616 ELEFGLHNYGADGKSVHSET-GWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFG 679
                ||....:....:||:. |..|.|    ..||.                            |
  Fly   975 ----GLETRQSKRSQLHSQAPGPGPPS----TQPHH----------------------------G 1003

  Fly   680 SISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISV 744
            :....|.:||.:.|...|.|..::.               |::|     ||.|....|
  Fly  1004 NNGVVTSAHPITVGALDVMNVKQVV---------------NRYG-----TLPKGARIG------- 1041

  Fly   745 KDEKILNHAIEIANEISARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAH 809
                               :.:|.:.|                       |.:.:..|..:..:.
  Fly  1042 -------------------AYLDSLED-----------------------SSEAAPALPATAPSL 1064

  Fly   810 TPTHGNASPFPKKKNFTEELQSIPDIQRFRS------------------LSEIKNSTDLRVPIFD 856
            .|.:|:|:|...:.|  .:...||..|..||                  |...:.:|:..:..|.
  Fly  1065 PPANGHATPPAARLN--PKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTEGTMMTFS 1127

  Fly   857 -----------KESSDFLFQKSREILSR------PLNL-----ERECGDEQPPKSIDDNIMDIEN 899
                       |.|:..:....:..|:.      ||:|     |.|.|...||.:.:..:..|:.
  Fly  1128 SFRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQ 1192

  Fly   900 TLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGISSATGSLKSAVYSYSNGVQTMFDFN 964
            .|.|                        |||:..::.:|                ||..     |
  Fly  1193 HLHA------------------------QLPNNGNISNG----------------NGTN-----N 1212

  Fly   965 AATSHLDKHLQYMHNQAQLSAAAPVDPKPMDDKRSSTPDTGFASRDTNISLSRRSSQKSSYSPQE 1029
            ..:||                         :|..:..|....||....:||.:|.....|.|.
  Fly  1213 NDSSH-------------------------NDVSNIAPSVEEASSRFGVSLRKREPSTDSCSS-- 1250

  Fly  1030 SFHFPLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIKSGVGLNASSGSVYM 1094
                       ..:||       ..||::|..|....|   :..|.||.:.:|.|:..
  Fly  1251 -----------LGSPP-------EDLKEKLITEIKAAG---KDTAPASHLANGSGIAV------- 1287

  Fly  1095 GSKGYRQRSTSFNESFHPISPVLSE----------PPQRERGVIQRQ-----VRLEQQQPLPRRS 1144
                           ..|:|.:::|          |||:::.:....     .:.:.::..|::.
  Fly  1288 ---------------VDPVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKM 1337

  Fly  1145 ASYKPRSIRARTLRRLSYNPMTLDSSSSSGEEPVKPSLARSECDIRARVAASSNSSLGRRRRAG- 1208
            ::..|::..|.|:.....:...:|..    :||..|:.|.:...:......::..:|.|:....
  Fly  1338 SAPMPKAEPANTIIDFKAHLRRVDKE----KEPATPAPAPATVAVANNANCNTTGTLNRKEDGSK 1398

  Fly  1209 ---------------MNRQVQSACHDEREVIISPRQMYGSNSSIKS-------APHY---NIGGQ 1248
                           .|..|::......|..:..|:..||.:|:|.       ||.|   .|..|
  Fly  1399 KFSQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTILQQ 1463

  Fly  1249 RRSFHRGGPGVMGGGYEQFQYDERIYDFGGRGPGNNYNMAQASYLSSSQKPSYLLNGSELP---- 1309
            :.|.      |.|||....|...:            |.|...:..:....|:.|  |::.|
  Fly  1464 QPSV------VNGGGTPNAQLSPK------------YGMKSGAINTVGTLPAKL--GNKQPPAAP 1508

  Fly  1310 --------GSGSGSSSAASSAVQATYRPGAGTSVQRPMSGGAALHEFDISRLTGKSPTSTNFVGS 1366
                    .|.|.::|.::|:...|.|..|.:::                    |:..||.....
  Fly  1509 PPPPPNCTTSNSSTTSISTSSRDCTSRQQASSTI--------------------KTSHSTQLFTD 1553

  Fly  1367 SPEELKQRQLSVG---------SL--QTP--NNKVAKPQRPTEFHWPEKIHASAVKQHEMHWRQV 1418
            ..|:.....|..|         ||  |.|  ..|.|.|.:||:.    .|:|:.:
  Fly  1554 DEEQSHTEGLGSGGQGSADMTQSLYEQKPQIQQKPAVPHKPTKL----TIYATPI---------- 1604

  Fly  1419 HQQQSLPTASIITAAVGGAVSARRSSDSSSSSSTESGDEFQFRREFVAPRIPPSPAPXLRKMLKY 1483
                                 |:.:..:||:|||      |..||.:...:     ..|...||:
  Fly  1605 ---------------------AKLTEPASSASST------QISRESILELV-----GLLEGSLKH 1637

  Fly  1484 VLNLLFGN 1491
            .:|.:.|:
  Fly  1638 PVNAIAGS 1645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	108/263 (41%)
		PTKc_Ack_like	137..398	CDD:270636	108/261 (41%)
		SH3	400..454	CDD:214620	9/60 (15%)
		CRIB	486..525	CDD:238077	10/82 (12%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	111/275 (40%)
		Pkinase_Tyr	389..640	CDD:285015	108/263 (41%)
		FABD	1584..1723	CDD:197885	21/108 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940