DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and lyn

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001004543.1	Gene:	lyn / 447804	ZFINID:	ZDB-GENE-040912-7	Length:	510	Species:	Danio rerio

Alignment Length:	320	Identity:	115/320 - (35%)
Similarity:	169/320 - (52%)	Gaps:	29/320 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 TMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHI--IPADSISVNKQLGTGEF 144
            :|:|.......|....||    .||....|:.        |.:|..  |..|||.:.|:||.|:|
Zfish   204 SMIKHYHKQSDGLCRKLD----KACEKPKAQK--------PWDKDAWEISKDSIKMVKKLGAGQF 256

  Fly   145 GIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLV 209
            |.|....::|..   :||:|.|....|...  .||:||.:|.:::|:.:||||.||..|:.:.::
Zfish   257 GEVWMAFYNNST---KVAVKTLKPGTMSVE--AFLEEANLMKTLQHDRLVRLYAVVTKTEPIYII 316

  Fly   210 TELAHLRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDK 273
            ||.....|||:.|| .:|.::.   :|.|.:|:.||..||.|:|:|..|||||.|.|:||.....
Zfish   317 TEYMANGSLLDFLKSQAGSKIQ---LPKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLL 378

  Fly   274 VKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGF 338
            .||:||||:|.  :..|.|..  ....|.||.|.|||.|||..||..||:|:|||.|:|:.:||.
Zfish   379 CKIADFGLARV--IEDDQYTA--REGAKFPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGK 439

  Fly   339 QPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
            .|:..::..:::.::.. .| |:.:|:.||.|.|.:|..||::....||.|..|...|.|
Zfish   440 IPYPGMSNSEVMSSVQR-GY-RMPRPENCPVELYEIMTTCWKNKPEDRPTFDYIQSVLDD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	100/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	100/261 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
lyn	NP_001004543.1	SH3_Lyn	65..120	CDD:212937
		SH2_Src_Lyn	123..223	CDD:198227	5/22 (23%)
		PTKc_Lyn	237..508	CDD:270657	105/275 (38%)
		Pkinase_Tyr	245..495	CDD:285015	100/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010