DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack-like and Shark

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster


Alignment Length:454 Identity:149/454 - (32%)
Similarity:224/454 - (49%) Gaps:81/454 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 TESELQQYYNAVKN-----ELKITN----------AAQFKYAADEDLRFIGLSRPEIRRLRKFYE 62
            ||.|||.....:|:     |....|          ||...|....:...|.:..|.|.:..:...
  Fly   506 TEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEV 570

  Fly    63 KHFPHSYLSKIKRLLQAPGTMVKREEAP---GGGSQVALD--------------------GSSAS 104
            ::|..|.::            ::||.|.   |.|.|..:|                    |.:||
  Fly   571 EYFTKSDVA------------IERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNAS 623

  Fly   105 ACSSLAA------KNGASSPS----KVPNNKHIIPADSISVNKQLGTGEFGIVQQGVW-----SN 154
            ..|.:|:      ....|:||    :....:..|..:.:.:::::|.||||.|..| |     ..
  Fly   624 TESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGA 687

  Fly   155 GNE-RIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSL 218
            |.| |::||||.|..|  .||..|||:||::|..:||:.||||.|:... :.||:|.|||.|.|:
  Fly   688 GEESRLEVAIKMLSDE--HSNKQEFLREASVMMRLEHKCIVRLIGIAKG-EMLMMVQELAPLGSM 749

  Fly   219 LECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSR 283
            |:.:.|.|..::  ....|..:|.||..||.|||.:..:||||||||||:.::.:.||||||:||
  Fly   750 LQYILDHGHEIT--ANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSR 812

  Fly   284 ALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQ 348
            :|..|...|:  |....:.||.|.|||..|...|::|||||:|||.:|||||.|..|:..::.:.
  Fly   813 SLRPGSTEYQ--FTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVD 875

  Fly   349 ILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRF---GEIYDQLPDMK--PEQLKAV 407
            .::.:|:.  :||.||:.||:..|.:|..||::....||.|   .|.:.:.||.:  ||.::.|
  Fly   876 AIKLVDSG--ERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQNLPELVQTV 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938 14/66 (21%)
STYKc 133..396 CDD:214568 112/271 (41%)
PTKc_Ack_like 137..398 CDD:270636 112/269 (42%)
SH3 400..454 CDD:214620 3/10 (30%)
CRIB 486..525 CDD:238077
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 112/268 (42%)
PTKc_Syk_like 666..926 CDD:270650 112/269 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468383
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24418
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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