DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and lck

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001001596.1	Gene:	lck / 414333	ZFINID:	ZDB-GENE-040617-1	Length:	503	Species:	Danio rerio

Alignment Length:	447	Identity:	131/447 - (29%)
Similarity:	195/447 - (43%)	Gaps:	99/447 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AQFKY--AADEDLRF--------IGLSRPEIRRLRKFY---EKHFPHSYLSKIK----------- 74
            |.:||  |..:||.|        :....||.......:   ..:.|.::::|:.
Zfish    60 AIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKN 124

  Fly    75 -------RLLQAPGT-----MVKREEAPGGGSQVA---LDGSSASACSSLAAKN----GASSPSK 120
                   |.|.|||.     :::..|...|...::   ||............:|    |....:|
Zfish   125 LSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNK 189

  Fly   121 VPNN------KHI------------------------------IPADSISVNKQLGTGEFGIVQQ 149
            :..|      ||.                              :|.:|:.:.::||.|:||.|..
Zfish   190 ISFNSLSELVKHYSREADGLCTRLVKPCQTRAPQKPWWQDEWEVPRESLKLERRLGQGQFGEVWM 254

  Fly   150 GVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAH 214
            |:::|..   |||||.|....|..:  .||.||.:|.|::|..:|||:.|| ..:.:.::||...
Zfish   255 GLYNNNR---QVAIKSLKPGTMSIS--AFLAEANLMKSLQHPRLVRLFAVV-TQEPIYIITEYME 313

  Fly   215 LRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDF 279
            ..||::.||..  ..|.:.|.||.:.|.|:..||.|:|||..|||||.|.||||..:...||:||
Zfish   314 NGSLVDFLKTP--EGSDIPINTLIDMAAQVAEGMAYVEQKNYIHRDLRAANILVSHELTCKIADF 376

  Fly   280 GLSRALGVGKDYYKTN---FNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPW 341
            ||:|.:       |.|   .....|.||.|.|||.|||..|:..||||:|||.|.|:.:||..|:
Zfish   377 GLARLI-------KNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVLLTEIVTYGRIPY 434

  Fly   342 AALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
            ..:|..:::..::. .| |:..||.||...|.:|..||.::...||.|..:...|.|
Zfish   435 PGMTNPEVIANLER-GY-RMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVLED 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	9/43 (21%)
		STYKc	133..396	CDD:214568	101/265 (38%)
		PTKc_Ack_like	137..398	CDD:270636	102/263 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
lck	NP_001001596.1	SH3_Lck	57..111	CDD:212938	10/50 (20%)
		SH2_Src_Lck	116..216	CDD:198225	15/99 (15%)
		PTKc_Lck_Blk	230..493	CDD:270652	105/277 (38%)
		Pkinase_Tyr	238..487	CDD:285015	101/265 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920