DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Csk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	99/266 - (37%)
Similarity:	157/266 - (59%)	Gaps:	19/266 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            :||...:.:.:.:|.||||.|..|:..|.    :||:|.|   :.:....:||.||::|.::||:
  Fly   794 VIPEAELQLRESIGKGEFGDVMLGILRNE----KVAVKML---KDEGAVQKFLAEASVMTTLEHD 851

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            |:|:..|:|..:..|.||||.....||::.|:..|.:  .:|......||....:||.|||.|::
  Fly   852 NLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQ--HITKKDQIIFAYDTASGMEYLEAKKV 914

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNAS 321
            :||||||||:|:......|:|||||:|     ::.|  |.:|. ||||.|.|||.:...||:|.|
  Fly   915 VHRDLAARNVLISEDCVAKVSDFGLAR-----EECY--NLDVG-KLPIKWTAPEALKNGRFSNKS 971

  Fly   322 DVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKR 386
            |:|:||:.|||::|:|..|:..:....:::.::. .| ::|.|:.||.|.|.:|.:.|..:.|||
  Fly   972 DMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEV-GY-KMEAPEGCPPEIYEMMRQAWDLNPAKR 1034

  Fly   387 PRFGEI 392
            |.|.|:
  Fly  1035 PTFAEL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	97/260 (37%)
		PTKc_Ack_like	137..398	CDD:270636	97/256 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	99/266 (37%)
		STYKc	800..1044	CDD:214568	97/260 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040