DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and LYN

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_011515831.1	Gene:	LYN / 4067	HGNCID:	6735	Length:	682	Species:	Homo sapiens

Alignment Length:	350	Identity:	122/350 - (34%)
Similarity:	178/350 - (50%)	Gaps:	55/350 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PEIRRLRKFYEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGAS 116
            |.|..:.|.|:|              ||.|...:.|:                ||.|       .
Human   372 PCISDMIKHYQK--------------QADGLCRRLEK----------------ACIS-------P 399

  Fly   117 SPSKVPNNKHI--IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFL 179
            .|.| |.:|..  ||.:||.:.|:||.|:||.|..|.::|..   :||:|.|....|  :...||
Human   400 KPQK-PWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNST---KVAVKTLKPGTM--SVQAFL 458

  Fly   180 KEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGLRVSFLTIPTLCEFALQ 243
            :||.:|.:::|:.:||||.||...:.:.::||.....|||:.|| |.|.:|   .:|.|.:|:.|
Human   459 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKV---LLPKLIDFSAQ 520

  Fly   244 ICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCA 308
            |..||.|:|:|..|||||.|.|:||......||:||||:|.: ...:|   ......|.||.|.|
Human   521 IAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI-EDNEY---TAREGAKFPIKWTA 581

  Fly   309 PECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYT 373
            ||.||:..||..||||:||:.|:|:.:||..|:...|...::.|: :..| |:.:.:.||.|.|.
Human   582 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTAL-SQGY-RMPRVENCPDELYD 644

  Fly   374 LMMKCWQDDAAKRPRFGEIYDQLPD 398
            :|..||::.|.:||.|..:...|.|
Human   645 IMKMCWKEKAEERPTFDYLQSVLDD 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	5/12 (42%)
		STYKc	133..396	CDD:214568	101/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/261 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
LYN	XP_011515831.1	SH3_Lyn	237..292	CDD:212937
		SH2_Src_Lyn	295..395	CDD:198227	9/52 (17%)
		PTKc_Lyn	409..680	CDD:270657	105/274 (38%)
		Pkinase_Tyr	417..667	CDD:285015	101/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920