DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Ack

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster

Alignment Length:	1249	Identity:	306/1249 - (24%)
Similarity:	486/1249 - (38%)	Gaps:	305/1249 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            |.:.|.|.:|:|:.:.::::|::|..|.|.|...:||...||.:|.||||.:...|...|.:...
  Fly    18 LEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRKN 82

  Fly    73 I-KRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVN 136
            | .:|:             |||.|.:....|::|..| :..||.....       :|....|::.
  Fly    83 ILSKLI-------------GGGKQPSSKKQSSAARES-SQGNGTQLTC-------LIHEKDITMG 126

  Fly   137 KQLGTGEFGIVQQGVW--SNGNERIQVAIKCLCRERMQSNPM--EFLKEAAIMHSIEHENIVRLY 197
            .:||.|.||:|::|.|  |...:.|.||:|.|..:.:....:  :|.:|...||:::|.|:||||
  Fly   127 LKLGDGSFGVVRRGEWSASPAGKVIPVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLY 191

  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLA 262
            |||| :..:|::||||...|||:.|:.. .|.:.|||  :..:::||..||.||||||.:|||||
  Fly   192 GVVL-SQPMMMITELAERGSLLDTLRKQ-CRHTSLTI--IWNWSVQIVTGMAYLEQKRFLHRDLA 252

  Fly   263 ARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFG 327
            .||:|:.:.:|:||.||||.|||....|.|.  .:.:.|:|..|||||.:.:.:|::|||.|.||
  Fly   253 CRNVLLAAGNKIKIGDFGLMRALPQEDDCYV--MSEHKKVPFPWCAPESLRFRQFSHASDTWMFG 315

  Fly   328 VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392
            |.||||||:|..||..|.|.|||..||... :||.|||.||.:.|.:|::||....|:||.|..:
  Fly   316 VTLWEMFSFGEDPWVGLNGSQILRKIDREG-ERLHQPDACPPDVYAMMLQCWDKTPAERPTFAAL 379

  Fly   393 YDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVA 457
            .:.|..|.|..::|       .:.|                         ...|.....|.:|:|
  Fly   380 KEYLASMSPPVMRA-------SRSH-------------------------HESKGLQIEPGDTIA 412

  Fly   458 FLEGLPSSTRDSFSRVSDHRISKRKLRTEM-ISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYN 521
            .::|                      |.|: :.|.||  :.|..:||
  Fly   413 IIDG----------------------RHELKLIKGQN--QRTFDIGI------------------ 435

  Fly   522 HVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHT 586
             .|:.:         :||..:                     ||.....|.:|:.
  Fly   436 -FPRNL---------LEQRKV---------------------GAAGDVVMRSSVG---------- 459

  Fly   587 PKLIATNGQSS--FDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPH 649
                  ||.||  |.|..|.....  ..|||.                     :....|:.:.||
  Fly   460 ------NGSSSSPFGFCWGGAAAM--ANGDDR---------------------QRKCASMTNQPH 495

  Fly   650 --EYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATG-------SH------PKSPGFDHVNN 699
              |....|..:.|.:||         :|      .:|||       .|      |:.|.......
  Fly   496 AKERKSTSSKQFAYNKL---------VN------DSATGLQRRNAVKHKGVVVGPQRPPPPQFQQ 545

  Fly   700 KNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARS 764
            :..:.::|..:...:....|...|.|...:|....|.           .||:..|::.....:..
  Fly   546 EGILIDISPDMRPIAEAGTGGAKGAGDSSSLQADSSF-----------CILDAPIDVPTYAGSSG 599

  Fly   765 MIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKKKNFTEEL 829
            ..||  :.:|..::.:.:|.|....::.:     .|.|........||:.|...|.:|::..::.
  Fly   600 SGDL--NVSPTYYNEQPQFDFDPAKMTAS-----PGRLQPPPYQMPPTYSNTMEFVQKRDLHQQQ 657

  Fly   830 QSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGDEQP----PKSI 890
            .:.|  .|.|...:..| .:..|.::..      |.:|.|..|.|..:.......:.    .||.
  Fly   658 LATP--VRERDPFDTTN-VETTVALYSN------FNQSLEAASPPAPIYNSPSVRKSLFGGSKSN 713

  Fly   891 DDNIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGI---SSATGSLKSAVYS 952
            .:||..:|:....|||..:    .|::.|:  |.:....|..|...||:   .|....|:..:||
  Fly   714 KENIPALESAAMQLNLSNL----TLERHDA--TCIQPVEPVPAPPGDGVLLDKSFIAELEKDMYS 772

  Fly   953 Y-SNGVQTMFDFNAATSHLDKHLQYMHNQAQL-SAAAP-------VDPKPMDDKRSSTPDTGFAS 1008
            . .|..|..:..|:...:..|.:.|..|...| :.|||       ..|......:.:..:...|:
  Fly   773 NGQNRAQEEYQRNSTQMYASKDMVYKQNLTPLKNGAAPGSVHSNHSSPSSTASPKQNNVEAAAAA 837

  Fly  1009 RDTNISLSRRSSQKSSYSPQESFHFPLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQML 1073
            ..|..|:..|...:...|.|..:         ::.||...:       :|..|:...:...:|..
  Fly   838 AATTQSVVNRIWYEQVASTQSEY---------YAQPPTEQA-------EEQIYQNHRHQQQQQQE 886

  Fly  1074 ASAS----------PIKSGVGLNAS---------SGSVYMGSKGYRQRSTSFNE-----SFHPIS 1114
            .:.|          |..:.....||         :||.|.|.......:..::|     ...|..
  Fly   887 LNHSFVAISNRVVAPKNNAYSSTASLYDAVAASTAGSTYYGQVPNGSGAVLYDEVTQDDYLRPTR 951

  Fly  1115 PVLSEPPQRERGVIQR---QVRLEQQQPLPRRSASYKP-RSIRARTLRRLSYNPMTLDSSSSSGE 1175
            |....||......|||   ::||:|||.|......|.| .|...|...:|  ..:..:..||:.|
  Fly   952 PAPLAPPPLSAQQIQRRMEKMRLQQQQQLDGAHQLYAPVPSDYGREQEKL--QQLMQELGSSAVE 1014

  Fly  1176 EPVKPSLARSECDI 1189
            :.|:.:|..:..|:
  Fly  1015 QDVRNALRAASGDV 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	20/56 (36%)
		STYKc	133..396	CDD:214568	118/266 (44%)
		PTKc_Ack_like	137..398	CDD:270636	118/264 (45%)
		SH3	400..454	CDD:214620	5/53 (9%)
		CRIB	486..525	CDD:238077	7/39 (18%)
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	20/56 (36%)
		PTKc_Ack_like	128..385	CDD:270636	118/263 (45%)
		UBA_TNK1	1031..1070	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850