Protein Alignment Ack-like and egfra

DIOPT Version :9

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: NP_919405.1
• Gene: egfra / 378478
• ZFINID: ZDB-GENE-030918-1
• Length: 1191
• Species: Danio rerio
• Alignment Length: 557
• Identity: 154/557 - (27%)
• Similarity: 241/557 - (43%)
• Gaps: 121/557 - (21%)

  Fly   117 SPS-KVPNNK--HIIPADSISVNKQLGTGEFGIVQQGVW--SNGNERIQVAIKCLCRERMQSNPM 176
            :|| :.||..  .|:........|.||:|.||.|.:|:|  ...|.:|.||||.|..........
Zfish   692 TPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVHKGLWVPEGENVKIPVAIKVLREATSPKANK 756

  Fly   177 EFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFA 241
            |.:.||.:|.|:||.::.||.|:.| |.::.|:|:|.....||:.::::..|:....:...|
Zfish   757 EIMDEAYVMASVEHPHVCRLLGICL-TSTVQLITQLMPYGCLLDYVRENKDRIGSQHLLNWC--- 817

  Fly   242 LQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAW 306
            :||..||.|||::.|:||||||||:||.:...|||:||||::.|...:..|..:..   |:||.|
Zfish   818 VQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGG---KVPIKW 879

  Fly   307 CAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEY 371
            .|.|.|.:..:|:.||||::||.:||:.::|.:|:..:...:|...::  ..:||.||..|..:.
Zfish   880 MALESIQHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLE--KGERLPQPPICTIDV 942

  Fly   372 YTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTP 436
            |.:|:|||..||..||||.|:..:...|          ..:|.:  .|..|||....|...:.:.
Zfish   943 YMIMVKCWMIDAESRPRFRELIAEFTKM----------ARDPSR--YLVIQGDDRMHLPSPSDSK 995

  Fly   437 FWKGVLS------TGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDF 495
            |::.::|      .....|..|::  :|... ||::|....    |.:|.
Zfish   996 FYRSLMSGELDEAVDADEYLVPNH--SFFSS-PSTSRTQLL----HSVSL--------------- 1038

  Fly   496 KHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLP--PTPT---SPDSLQ 555
                     .::||:.    :|:|.|..|            :.:..::|.  |.||   .....|
Zfish  1039 ---------NSSFGNC----NSRNGNGYP------------VRENSMVLRYIPDPTERFQEGDFQ 1078

  Fly   556 TASGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFD---------FASG-------- 603
            .|.|| .|..|...:  :.:||.:  ...|.|.....:...:.|         |.|.
Zfish  1079 PAPGY-NEYMNQNES--SMINPVY--QQPHGPPRTLLHSSPALDETEEEYLNCFKSPAPASVVEY 1138

  Fly   604 ---------STNPFF----PNRGDD--ELEFGLHNYG 625
                     ||.|||    |:...|  .||...|..|
Zfish  1139 LNTSHTQLLSTKPFFSMDNPDYQQDFCPLELKTHTNG 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	98/264 (37%)
		PTKc_Ack_like	137..398	CDD:270636	98/262 (37%)
		SH3	400..454	CDD:214620	10/59 (17%)
		CRIB	486..525	CDD:238077	5/38 (13%)
egfra	NP_919405.1	Recep_L_domain	54..166	CDD:279382
		Furin-like	184..333	CDD:279142
		FU	229..274	CDD:238021
		Recep_L_domain	359..479	CDD:279382
		GF_recep_IV	503..634	CDD:291509
		FU	550..596	CDD:214589
		PTKc_EGFR	703..1014	CDD:270683	108/331 (33%)
		Pkinase_Tyr	711..967	CDD:285015	98/264 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910