DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Fak

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001137718.1	Gene:	Fak / 37233	FlyBaseID:	FBgn0020440	Length:	1500	Species:	Drosophila melanogaster

Alignment Length:	1316	Identity:	303/1316 - (23%)
Similarity:	475/1316 - (36%)	Gaps:	361/1316 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EFLTESELQQY---YNAVKNELKITNAAQFKYAADEDLRFI--GLSRPE---------IRRLRKF 60
            |..||.|||.:   ...:|.::||:.:...     |||...  |::..|         .|.|.|.
  Fly   326 ENTTEPELQNFNCNCQKIKTQIKISASNNV-----EDLVITCNGINTAESIADLIDGYCRLLSKD 385

  Fly    61 YEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSS--------------LAA 111
            .|....|.            .|....|::.......|..||:.|..|.              |..
  Fly   386 LEFTIWHR------------ETNASNEDSAKALPNDATLGSNKSTSSQGKPMLTDDYAEIGLLEG 438

  Fly   112 KNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVW-----------------SNGNER- 158
            :...|:|: |.|  :.:....|:.:.::|.|:||.|..|.:                 ||.::|
  Fly   439 EGDYSTPT-VRN--YELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRN 500

  Fly   159 -------IQVAIKCLCRERMQSNPME-FLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHL 215
                   |||||| .|:........| ||.||.||...:|.:|:||.| :.:...:.:|.|||.|
  Fly   501 ADSRPDVIQVAIK-TCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIG-ICSVMPIWIVMELAKL 563

  Fly   216 RSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFG 280
            ..|...||.:..|:|.   .||.::..|:...:.|||.|:.:|||:||||:||.|...||::|||
  Fly   564 GELRAYLKTNSERLSH---GTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFG 625

  Fly   281 LSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALT 345
            |||.:.....|:.|   ..:.|||.|.:||.||:.|||.|||||.||||:||:...|.:|:..:.
  Fly   626 LSRWVSDQSYYHST---PTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVK 687

  Fly   346 GLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD------------ 398
            ...::..::  |.:||..|..||...|:||.:||..:..|||.|..|.:.|.:
  Fly   688 NSDVILKLE--NGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSET 750

  Fly   399 MKPEQLKAVVNCT---------EPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSN 454
            :|.||.| |.:.:         .|.|...:....||..::...||.|          ..|....|
  Fly   751 LKREQRK-VASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLP----------QTYIIAQN 804

  Fly   455 TVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQN 519
            .....:.:..:             .||.:.....:.|.:.| :|..||:|          .|:.|
  Fly   805 PAVLAKLMMEN-------------QKRGINPAAYTTPASVF-NTLAVGLD----------DSNPN 845

  Fly   520 YNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAE 584
            .:     :.|...|:.|:    |.|.|...| :.|::........:.....:..|:||
  Fly   846 VS-----LKTTKLPAADL----LKLDPIAES-ERLRSQFSANSSASQLANPLTASVNP------- 893

  Fly   585 HTPKLIATNGQSSFDFASGSTNPFFPNRGDDELE------------FGLHNYGA-------DGKS 630
            |........|..:....|.|:....|.:.::.::            .|...||:       ..|:
  Fly   894 HESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENISNPSVSKVSGYSLYGSLERHQPPPAKA 958

  Fly   631 VHSETG------------------WRP---------TSRSIVDDP--HEYHEISDDEIAADKLDF 666
            :||:.|                  .:|         .|||:..:.  |.|.:.....|..:
  Fly   959 MHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERSRSMERNTYFHAYRQQMKTSIECE---- 1019

  Fly   667 GPSLLDEINSMFGSISAAT-GSHPKSPGFDHVNNKNEITEMSAKLGQKSG------------DTN 718
              :|.:||.. ||.|...| .|..:.|.|..:.|..     .|:|||...            |:.
  Fly  1020 --ALPEEIYD-FGGIGLKTCVSARQQPKFSPMVNVR-----PAELGQVQNTDCMGLQQNIPMDSF 1076

  Fly   719 GNKHGHGLLPTLSKKK-------SSG----TVKP-ISVKD----------EKILNHAI-EIANEI 760
            |....|.|..:|..::       :||    ||.| ||:.:          |.:.|..| .:..|.
  Fly  1077 GVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQAEAMGNQGIHNVLGEK 1141

  Fly   761 SARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLG--TSGSAHTPTHGNASPFPKKK 823
            ..:...|..||...:|.....: |...|..|.|....:...|.  ::|.:..|...|:|..|...
  Fly  1142 LRQQQKDSNSDSEWLIQEELLR-SCSIPQGSLNDHQAQMFKLDFMSAGPSSLPDCSNSSSRPMTP 1205

  Fly   824 NFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGD----- 883
            |              .:||.:|::                 ..|.:.||...:.|.:.|.
  Fly  1206 N--------------ANLSSLKSN-----------------HSSADHLSSLTSAEEQMGSNARNL 1239

  Fly   884 -----EQPPKSIDD-----------NIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHM 932
                 .:||...||           :||.:...::..|.:   .|.||.|:      :..:|.::
  Fly  1240 GSAVPSRPPNRADDEVYCATTLVVKSIMALSQGVEKANTE---GYLELVKN------VGVKLRNL 1295

  Fly   933 ASLDDGIS-----SATGSLKSAVYSYSNGVQTMFD-FNAATSHLDKHLQYMHNQAQLSAA--APV 989
            .:..|.||     .|...::.|....|..:..:.. ...|..:.|..|...:.::.||||  ..:
  Fly  1296 LTSVDKISIIFPAQALKEVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAM 1360

  Fly   990 DPKPMDDKRSST--------PDTGFASRDTNISLSRRSSQKSSYSPQESFHFPLKGEPLFSAPPV 1046
            |.|.:.|...|.        |.:  |:::|:.|.|..|:..|                 ..|.||
  Fly  1361 DAKNLFDVVDSIRQRYQHLFPPS--ATKETSCSSSFESTSGS-----------------IVAEPV 1406

  Fly  1047 VMSGGY------ASLKDELG-YERFGNGATKQMLASASPIKSGVGLNASSGSVYMGSKGYRQRST 1104
            ...|||      ..|....| |:...:.:....|...:| |:.:.| :..||:..|.......:.
  Fly  1407 NDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNP-KASIDL-SGGGSLQRGMSLGLDTTR 1469

  Fly  1105 SFNESFHPISPVLSEP 1120
            |.||....:...|..|
  Fly  1470 STNEPLRIVEETLGSP 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	18/68 (26%)
		STYKc	133..396	CDD:214568	106/288 (37%)
		PTKc_Ack_like	137..398	CDD:270636	106/286 (37%)
		SH3	400..454	CDD:214620	13/62 (21%)
		CRIB	486..525	CDD:238077	8/38 (21%)
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	19/84 (23%)
		PTKc_FAK	450..744	CDD:133187	107/303 (35%)
		Pkinase_Tyr	462..736	CDD:285015	105/283 (37%)
		Focal_AT	1249..1376	CDD:281606	27/135 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468384
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840