DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Ror

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_476962.1	Gene:	Ror / 34367	FlyBaseID:	FBgn0010407	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	105/274 - (38%)
Similarity:	148/274 - (54%)	Gaps:	11/274 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 KQLGTGEFGIVQQGVWSNGNE-RIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVV 200
            ::||.|.||.|.:|.....|: .|.||||.|..........:|.:|..::..::|:|||.:.|||
  Fly   414 EELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVV 478

  Fly   201 LATDSLMLVTELAHLRSLLECL-KDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            |..:...::.|......|.|.| .:|......|:.....:.||||..||:||.....:|||||||
  Fly   479 LNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAAR 543

  Fly   265 NILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLK--LPIAWCAPECINYLRFTNASDVWAFG 327
            |.||.....||||||||||.: ...|||:    |..|  ||:.|...|.|.|.:||..||||:||
  Fly   544 NCLVNEGLVVKISDFGLSRDI-YSSDYYR----VQSKSLLPVRWMPSESILYGKFTTESDVWSFG 603

  Fly   328 VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392
            |.|||::|||.||:...:..:::..|  .:.|.|..|:.||:..|:||::||.:.:.|||.|.:|
  Fly   604 VVLWEIYSYGMQPYYGFSNQEVINLI--RSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDI 666

  Fly   393 YDQLPDMKPEQLKA 406
            .::|........||
  Fly   667 SNRLKTWHEGHFKA 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	102/262 (39%)
		PTKc_Ack_like	137..398	CDD:270636	103/264 (39%)
		SH3	400..454	CDD:214620	2/7 (29%)
		CRIB	486..525	CDD:238077
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568
		KR	235..312	CDD:214527
		PTKc_Ror	404..673	CDD:270642	103/265 (39%)
		Pkinase_Tyr	410..670	CDD:285015	102/262 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910