DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Btk29A

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	132/445 - (29%)
Similarity:	200/445 - (44%)	Gaps:	93/445 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPE-----IRRLR---------- 58
            ||.:.:|  |:::..||:.|.........|...:.|  :||.|.|     :.|.|
  Fly   369 YEVIDDS--QEHWWKVKDALGNVGYIPSNYVKPKAL--LGLERYEWYVGDMSRQRAESLLKQGDK 429

  Fly    59 ---------------------KFYEKHFPH----------SYLSKIKRLLQAPGTMVKREEAPGG 92
                                 |..:.|..|          .|||: |...:....::.......|
  Fly   430 EGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE-KHCCETIPDLINYHRHNSG 493

  Fly    93 GSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNE 157
            |....|   .:|.|..........|     ::|..|....:.:.::||:|:||:|::|.|...
  Fly   494 GLACRL---KSSPCDRPVPPTAGLS-----HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGS-- 548

  Fly   158 RIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECL 222
             |..|:|.:....|..:  :|::||.:|..::|.|:|:||||......:.:|||.....|||..|
  Fly   549 -IDTAVKMMKEGTMSED--DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYL 610

  Fly   223 K--------DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDF 279
            :        :.||         |.:..:|:..||.|||:...|||||||||.||.|::.||::||
  Fly   611 RRHEKTLIGNMGL---------LLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADF 666

  Fly   280 GLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAAL 344
            ||:|.  |..|.|.::...  |.||.|..||.:||.||::.|||||:||.:||:|:.|..|:..|
  Fly   667 GLARY--VLDDQYTSSGGT--KFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRL 727

  Fly   345 TGLQILEAIDAPNYQR---LEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            ...:::|.:     ||   ||:|..|..|.|.:|..||.....:||.|..:.|||
  Fly   728 KNTEVVERV-----QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	16/91 (18%)
		STYKc	133..396	CDD:214568	100/273 (37%)
		PTKc_Ack_like	137..398	CDD:270636	102/271 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	8/31 (26%)
		SH2_Tec_family	403..505	CDD:198188	17/105 (16%)
		PTKc_Tec_like	521..778	CDD:173637	103/280 (37%)
		Pkinase_Tyr	526..777	CDD:285015	100/273 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950