DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and src

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_017209008.1	Gene:	src / 325084	ZFINID:	ZDB-GENE-030131-3809	Length:	549	Species:	Danio rerio

Alignment Length:	298	Identity:	111/298 - (37%)
Similarity:	158/298 - (53%)	Gaps:	29/298 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            ||.||:.::.:||.|.||.|..|.| ||..|  ||||.|....|  :|..||:||.:|..:.||.
Zfish   278 IPRDSLRLDVKLGQGCFGEVWMGTW-NGTTR--VAIKTLKPGTM--SPEAFLQEAQVMKKLRHEK 337

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            :|:||.|| :.:.:.:|||.....|||:.|| |.|   ..|.:|.|.:.|.||.:||.|:|:...
Zfish   338 LVQLYAVV-SEEPIYIVTEYMGQGSLLDFLKGDMG---KMLRLPQLVDMASQIASGMAYVERMNY 398

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNAS 321
            :||||.|.||||......|::||||:|.: ...:|   ......|.||.|.|||...|.|||..|
Zfish   399 VHRDLRAANILVGDNLVCKVADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGRFTIKS 459

  Fly   322 DVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKR 386
            |||:||:.|.|:.:.|..|:..:...::|:.::. .| |:..|..||...:.||:.||:.:..:|
Zfish   460 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GY-RMPCPAECPDSLHELMLTCWRKEPEER 522

  Fly   387 PRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            |.|..:...|.|        ....|||:     |:.|:
Zfish   523 PTFEYLQGFLED--------YFTSTEPQ-----YQPGE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	100/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/261 (39%)
		SH3	400..454	CDD:214620	5/25 (20%)
		CRIB	486..525	CDD:238077
src	XP_017209008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010