DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and sev

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	112/338 - (33%)
Similarity:	172/338 - (50%)	Gaps:	43/338 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LAAKNGASSPSKVPNNKHIIPA---DSISVNKQLGTGEFGIVQQG--VWSNGNERIQVAIKCLCR 168
            :|.:|.|.|.:....:..::|.   ..:.:.:.||:|.||.|.:|  ...:..|..:||||.|
  Fly  2182 MAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSL-- 2244

  Fly   169 ERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTE-------LAHLRSLLECLKDSG 226
            .:..|...|.|:||.:|.:.:|||||.|.|:...|:|:.|:.|       |::||:.........
  Fly  2245 RKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEP 2309

  Fly   227 LRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVF----SKDK---VKISDFGLSRA 284
            ...:.|::..|....:.:.||..|||....:|||||.||.||.    |.|:   |||.||||:|
  Fly  2310 QPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLAR- 2373

  Fly   285 LGVGKDYYKTNF----NVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALT 345
                 |.||:::    ...| ||:.|.:||.:....||..||||||||..||:.:.|.||:||..
  Fly  2374 -----DIYKSDYYRKEGEGL-LPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARN 2432

  Fly   346 GLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL----PDMKPEQLKA 406
            ..::|..:....  ||:||..|..:.|:|::.||:.|..:||.|...|:.|    .|::..|:.:
  Fly  2433 NFEVLAHVKEGG--RLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMAS 2495

  Fly   407 -----VVNCTEPK 414
                 ||:|:.|:
  Fly  2496 ATADTVVSCSRPE 2508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	100/282 (35%)
		PTKc_Ack_like	137..398	CDD:270636	101/284 (36%)
		SH3	400..454	CDD:214620	5/20 (25%)
		CRIB	486..525	CDD:238077
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020
		FN3	1993..2111	CDD:238020
		Pkinase_Tyr	2209..2481	CDD:285015	100/282 (35%)
		PTKc_c-ros	2213..2483	CDD:270640	101/280 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910