DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Lck

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_006238994.1	Gene:	Lck / 313050	RGDID:	2994	Length:	520	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	120/344 - (34%)
Similarity:	181/344 - (52%)	Gaps:	34/344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQV-----ALDGSSASACSSLAAKNGASSPSKVP 122
            ||:      ||:.|......:..|...||....|     |.||    .|:.|:.......|.| |
  Rat   190 KHY------KIRNLDNGGFYISPRITFPGLHDLVRHYTNASDG----LCTKLSRPCQTQKPQK-P 243

  Fly   123 --NNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIM 185
              .::..:|.:::.:.::||.|:||.|..|.: ||:.:  ||:|.|.:..|  :|..||.||.:|
  Rat   244 WWEDEWEVPRETLKLVERLGAGQFGEVWMGYY-NGHTK--VAVKSLKQGSM--SPDAFLAEANLM 303

  Fly   186 HSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMR 249
            ..::|..:||||.|| ..:.:.::||.....||::.|| .||::   |.:..|.:.|.||..||.
  Rat   304 KQLQHPRLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIK---LNVNKLLDMAAQIAEGMA 364

  Fly   250 YLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINY 314
            ::|::..|||||.|.||||......||:||||:|.: ...:|   ......|.||.|.|||.|||
  Rat   365 FIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY---TAREGAKFPIKWTAPEAINY 425

  Fly   315 LRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCW 379
            ..||..||||:||:.|.|:.::|..|:..:|..::::.:: ..| |:.:||.||.|.|.|||.||
  Rat   426 GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLE-KGY-RMVRPDNCPEELYHLMMLCW 488

  Fly   380 QDDAAKRPRFGEIYDQLPD 398
            ::....||.|..:...|.|
  Rat   489 KERPEDRPTFDYLRSVLDD 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	1/1 (100%)
		STYKc	133..396	CDD:214568	100/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/261 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Lck	XP_006238994.1	SH3_Lck	76..129	CDD:212938
		SH2_Src_Lck	134..234	CDD:198225	14/53 (26%)
		PTKc_Lck_Blk	248..511	CDD:270652	103/275 (37%)
		Pkinase_Tyr	256..505	CDD:285015	100/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010