DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and HCK

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_002101.2	Gene:	HCK / 3055	HGNCID:	4840	Length:	526	Species:	Homo sapiens

Alignment Length:	446	Identity:	135/446 - (30%)
Similarity:	207/446 - (46%)	Gaps:	98/446 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AQFKYAA--DEDLRF------IGLSRP----EIRRLRKFYEKHFPHSYLSKI------------- 73
            |.:.|.|  .|||.|      :.|...    :.|.|....|.:.|.:|::::
Human    85 ALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGI 149

  Fly    74 -----KRLLQAPGTMV------------------KREEAPGGGSQV------ALDG--------- 100
                 :|.|.|||.|:                  .|:..|..|..|      .||.
Human   150 SRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRS 214

  Fly   101 --------------SSASACSSLAAKNGASSPSKVPNNKHI--IPADSISVNKQLGTGEFGIVQQ 149
                          .:...|..|:....:|.|.| |..|..  ||.:|:.:.|:||.|:||.|..
Human   215 TFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQK-PWEKDAWEIPRESLKLEKKLGAGQFGEVWM 278

  Fly   150 GVWSNGNERIQVAIKCLCRERMQSNPME-FLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELA 213
            ..:   |:..:||:|.:   :..|..:| ||.||.:|.:::|:.:|:|:.|| ..:.:.::||..
Human   279 ATY---NKHTKVAVKTM---KPGSMSVEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFM 336

  Fly   214 HLRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKIS 277
            ...|||:.|| |.|   |...:|.|.:|:.||..||.::||:..|||||.|.||||.:....||:
Human   337 AKGSLLDFLKSDEG---SKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIA 398

  Fly   278 DFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWA 342
            ||||:|.: ...:|   ......|.||.|.|||.||:..||..||||:||:.|.|:.:||..|:.
Human   399 DFGLARVI-EDNEY---TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP 459

  Fly   343 ALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
            .::..:::.|::. .| |:.:|:.||.|.|.:||:||::...:||.|..|...|.|
Human   460 GMSNPEVIRALER-GY-RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	11/42 (26%)
		STYKc	133..396	CDD:214568	98/264 (37%)
		PTKc_Ack_like	137..398	CDD:270636	99/262 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
HCK	NP_002101.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH3	82..137	CDD:302595	13/51 (25%)
		SH2_Src_HCK	140..243	CDD:198226	14/102 (14%)
		PKc_like	254..524	CDD:304357	103/276 (37%)
		Pkinase_Tyr	262..511	CDD:285015	98/264 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920