DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Txk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001019426.1	Gene:	Txk / 305311	RGDID:	1306481	Length:	526	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	126/416 - (30%)
Similarity:	197/416 - (47%)	Gaps:	62/416 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTESELQQYYNAVKNELKITNAAQFKYAADE------DLRFIGLSRPEI-RRLRKFYEKHFPHSY 69
            ||..|..::|:  ||..:.......:..|.|      |.|.:|.....: .|.|:..:....|..
  Rat   141 LTNLETYEWYH--KNITRDQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQ 203

  Fly    70 LSK----------------IKRLLQ-----APGTMVKREEAPGGGSQVALDGSSASACSSLAAKN 113
            :.|                :..|:|     |.|.| .|...|     |.|.||...|.|..:.:.
  Rat   204 IKKNDSGQWYVTERHLFPSVPELIQYHQYNAAGLM-SRLRYP-----VGLLGSCLPATSGFSYEK 262

  Fly   114 GASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEF 178
            ....||:            ::..|::|:|:||:|..|.|   ..||:||||.:....|...  :|
  Rat   263 WEIDPSE------------LTFVKEIGSGQFGVVYLGEW---RARIRVAIKAINEGSMSEE--DF 310

  Fly   179 LKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQ 243
            ::||.:|..:.|..:|:||||.:....|.:|||......||:.|::...::....:.::|:   .
  Rat   311 IEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGKLPKALLLSMCQ---D 372

  Fly   244 ICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCA 308
            ||.||.|||:...|||||||||.||.|...|||||||::|.: :..:|..::   ..|.|:.|..
  Rat   373 ICEGMAYLEKSCYIHRDLAARNCLVSSACVVKISDFGMARYV-LDDEYISSS---GAKFPVKWSP 433

  Fly   309 PECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYT 373
            ||..::.::::.||||:|||.:||:|:.|..|:...:.||::|||.  ...||.:|...|...|.
  Rat   434 PEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS--KGFRLYRPHLAPMSIYG 496

  Fly   374 LMMKCWQDDAAKRPRFGEIYDQLPDM 399
            :|..||.:....||.|.|:...|.::
  Rat   497 VMYSCWHESPKGRPTFAELLQVLAEI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	13/59 (22%)
		STYKc	133..396	CDD:214568	95/262 (36%)
		PTKc_Ack_like	137..398	CDD:270636	96/260 (37%)
		SH3	400..454	CDD:214620	126/416 (30%)
		CRIB	486..525	CDD:238077
Txk	NP_001019426.1	SH3_TXK	84..138	CDD:212840
		SH2_Tec_Txk	142..247	CDD:198261	22/112 (20%)
		PKc_like	265..520	CDD:304357	97/280 (35%)
		Pkinase_Tyr	270..519	CDD:285015	95/262 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910