DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Abl2

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_038946666.1	Gene:	Abl2 / 304883	RGDID:	1590898	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	241/1044 - (23%)
Similarity:	375/1044 - (35%)	Gaps:	324/1044 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IDLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSR----PEIRRLRKFYEKHFP 66
            :.||:|:...:         |.|.||..        |.||.:|.::    .|:|  .|..:...|
  Rat   113 VALYDFVASGD---------NTLSITKG--------EKLRVLGYNQNGEWSEVR--SKNGQGWVP 158

  Fly    67 HSYLSKIKRL---------------------LQAPGTMVKREEAPGGGSQVAL--DG-------- 100
            .:|::.:..|                     |.....:|:..|:..|...::|  :|
  Rat   159 SNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 223

  Fly   101 ---------SSASACSSLA--------AKNGASSPSKVP---------------NNKHIIPADSI 133
                     ::.|..|:||        ..:|..:....|               ::|..:....|
  Rat   224 TTTDSKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDI 288

  Fly   134 SVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYG 198
            ::..:||.|::|.|..|||...:  :.||:|.|..:.|:..  |||||||:|..|:|.|:|:|.|
  Rat   289 TMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKEDTMEVE--EFLKEAAVMKEIKHPNLVQLLG 349

  Fly   199 VVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAA 263
            |........:|||.....:||:.|::.....  :|...|...|.||.:.|.|||:|..|||||||
  Rat   350 VCTLEPPFYIVTEYMPYGNLLDYLRECSREE--VTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412

  Fly   264 RNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGV 328
            ||.||.....||::|||||| |..|..|   ..:...|.||.|.|||.:.|..|:..||||||||
  Rat   413 RNCLVGENHVVKVADFGLSR-LMTGDTY---TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 473

  Fly   329 CLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIY 393
            .|||:.:||..|:..:...|:.:.:: ..| |:|||:.||.:.|.||..||:...|.||.|.|.:
  Rat   474 LLWEIATYGMSPYPGIDLSQVYDLLE-KGY-RMEQPEGCPPKVYELMRACWKWSPADRPSFAETH 536

  Fly   394 DQLPDM---------------KPEQLKAVVNCTE-----------PKKDHLLYRQGDIISVLDRN 432
            .....|               ..|:|....:.:.           |.|...|.:||:....||..
  Rat   537 QAFETMFHDSSISEDFVFFTEVAEELGRTASSSSVVPYLPRLPLLPSKTRTLKKQGENKENLDGG 601

  Fly   433 TGTPFWKGVL--STGKTGYFNPSNTVAFLEGLPSSTRDS-------------FSRVSDHR----- 477
            ...   ..:|  |:...|:...:...:....||...||.             |:|  |.:
  Rat   602 LDA---SEILASSSAPAGFIRSTQASSGSPALPRKQRDKSPSSLLEDAKETCFTR--DRKGGFFS 661

  Fly   478 --ISKRKLR---------TEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPY 531
              :.||...         .||.::|...::.||:       |..:|.|..:..::..|.|
  Rat   662 SFMKKRNAPMPPKRSSSFREMENQPHKKYELTGN-------FSPVASLQHADGFSFTPGQ----- 714

  Fly   532 KPSEDIEQTPLLLPPTPTSPDSLQTASGYF-------PEGANSGGAMGTSMNPTFIPSAEHTPKL 589
                   |...|:|        .:...|.|       .:.:..||..||:.......:...||:|
  Rat   715 -------QESNLVP--------AKCYGGSFAQRNLCGDDDSGGGGGSGTAAGGWSGITGFFTPRL 764

  Fly   590 I-ATNG-QSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYH 652
            | .|.| ::....||..|:..||.               ...:....:|.....|..:..|....
  Rat   765 IKKTLGLRAGKPTASDDTSKPFPR---------------SNSTSSMSSGLPEQDRMAMTLPRNCQ 814

  Fly   653 EISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDT 717
            .        .||..             ..:.:|.|.|:    ::|:..|::      |.:||.:
  Rat   815 R--------SKLQL-------------ERTVSTSSQPE----ENVDRANDM------LPKKSEE- 847

  Fly   718 NGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQ-------TPV 775
                   |..|...:.|:            |:|...   |..::.|:....:::.       ..|
  Rat   848 -------GAAPARERPKA------------KLLPRG---ATALALRAPDPAITESDCPGVGVAGV 890

  Fly   776 IHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTP--------------THGNASPF---PKKK 823
            ..:||.|        ..|| |.:.|..|....|..|              ||.:..|.   |..|
  Rat   891 AAAPKGK--------ERNG-GTRLGVAGVPEDAEQPGWSSPAKAVAVLPTTHNHKVPVLISPTLK 946

  Fly   824 NFTEELQSI-PDIQ--RFRSLSE--IKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGD 883
            :...::|.| .|.|  :|:.|||  :.:|.|                     ..||..::.:|..
  Rat   947 HTAADVQLIGTDSQGNKFKLLSEHQVTSSGD---------------------KDRPRRVKPKCAP 990

  Fly   884 EQPP 887
            ..||
  Rat   991 PPPP 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	14/62 (23%)
		STYKc	133..396	CDD:214568	108/262 (41%)
		PTKc_Ack_like	137..398	CDD:270636	107/260 (41%)
		SH3	400..454	CDD:214620	12/66 (18%)
		CRIB	486..525	CDD:238077	8/38 (21%)
Abl2	XP_038946666.1	SH3_Abl	111..164	CDD:212784	16/69 (23%)
		SH2_ABL	169..262	CDD:198189	11/92 (12%)
		PTKc_Abl	281..543	CDD:270645	108/273 (40%)
		FABD	1069..1188	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910