DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ack-like and Tnk2

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:XP_038944232.1 Gene:Tnk2 / 303882 RGDID:1305957 Length:1109 Species:Rattus norvegicus


Alignment Length:1336 Identity:326/1336 - (24%)
Similarity:513/1336 - (38%) Gaps:411/1336 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRL------RKFYEKHFP 66
            |.|.|:|.:||||:..::::|.||..:.|:|..:|||..||:.||..|||      ||...|.  
  Rat    42 LLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKR-- 104

  Fly    67 HSYLSKI----KRLLQAP-----GTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVP 122
            .|::||:    ::..:.|     .|..|....|||   :|.:|:..|....:..|:         
  Rat   105 KSWMSKVFSGKRQEAEFPSHHSQSTFRKPSPTPGG---LAGEGTLQSLTCLIGEKD--------- 157

  Fly   123 NNKHIIPADSISVNKQLGTGEFGIVQQGVW-SNGNERIQVAIKCLCRERMQSNPM---EFLKEAA 183
                      :.:.::||.|.||:|::|.| :...:.:.||:||| :..:.|.|.   :|::|..
  Rat   158 ----------LRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCL-KPDVLSQPEAMDDFIREVN 211

  Fly   184 IMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECL-KDSGLRVSFLTIPTLCEFALQICNG 247
            .|||::|.|::||||||| |..:.:|||||.|.|||:.| |..|   .|| :.||..:|:|:..|
  Rat   212 AMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKHQG---HFL-LGTLSRYAVQVAEG 271

  Fly   248 MRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECI 312
            |.|||.||.|||||||||:|:.::|.|||.||||.|||....|:|.  ...:.|:|.||||||.:
  Rat   272 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYV--MQEHRKVPFAWCAPESL 334

  Fly   313 NYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMK 377
            ....|::|||.|.|||.|||||:||.:||..|.|.|||..||... :||.:|:.||.:.|.:|::
  Rat   335 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEG-ERLPRPEDCPQDIYNVMVQ 398

  Fly   378 CWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV- 441
            ||......||.|..:.|.|.:.:|..::|:.:..||.|.|:  :..|:|:|::......:|:|. 
  Rat   399 CWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHI--QMNDVITVIEGRAENYWWRGQN 461

  Fly   442 LSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKP-QNDFKHTGHVGIDG 505
            ..|...|.| |.|.|..:.||  |.:|                   ||:| ||.|.||||...|.
  Rat   462 TRTLCVGPF-PRNVVTSVAGL--SAQD-------------------ISQPLQNSFIHTGHGDSDP 504

  Fly   506 A-TFG-----DIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEG 564
            . .:|     |..:||:..:...:....::..:|::.:.:.....||.|..| ::.|.|.:    
  Rat   505 RHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPTQHLGRMKREPPPRPPQP-AIFTHSKW---- 564

  Fly   565 ANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGK 629
             ...|.:|              |:.:               :|..|                   
  Rat   565 -GCSGCLG--------------PRPL---------------SPLSP------------------- 580

  Fly   630 SVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGF 694
                          ::::| .|..:|:|.             |.::|.|..:.....:.|:... 
  Rat   581 --------------LLEEP-TYDPVSEDP-------------DPLSSDFKRLGLRKPALPRGLW- 616

  Fly   695 DHVNNKNEITEMSAKL-GQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIAN 758
                    :.:.||:: |.|:|.::|   |...|....::..:.|.:|.:....::         
  Rat   617 --------LAKPSARVPGTKAGRSSG---GEVTLIDFGEEPVAPTPRPCAPSLAQL--------- 661

  Fly   759 EISARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKKK 823
            .:.|.|::|....|:|....|:                              |.|          
  Rat   662 AMDACSLLDKTPPQSPTRALPR------------------------------PLH---------- 686

  Fly   824 NFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGDEQPPK 888
                                       ..|:.|.:             :|||         .||.
  Rat   687 ---------------------------PTPVVDWD-------------ARPL---------PPPP 702

  Fly   889 SIDD--------NIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGI---SSA 942
            :.||        .:..|.:||.:..|.     |...:.::|...:.:|.....:|:|.:   ...
  Rat   703 AYDDVAQDEDDFEVCSINSTLVSAGLP-----TGPSQGETNYAFVPEQAQLPPALEDNLFLPPQG 762

  Fly   943 TGSLKSAVYSYSNGVQTMFDFNAATSHLDKHLQYMHNQ------------AQLSAAAPVDPKPMD 995
            .|...|:       .||...|.|......:.||....|            .|:....|:.|:|  
  Rat   763 GGQPPSS-------AQTAEIFQALQQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIPPRP-- 818

  Fly   996 DKRSSTPDTGF---------ASRDTNISLSRRSSQKSSYSPQESFHFPLKGEPLFSAPPVVMSGG 1051
                :.|..|.         |||....|...|...:...|||.|           ..|..::..|
  Rat   819 ----TRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREPLSPQGS-----------RTPSPLVPPG 868

  Fly  1052 YASLKDELG---------YERFGNG---ATKQMLASASPIKSGV--------GLNASSGSVYM-- 1094
            .:.|...|.         .:.|.:.   ||.|::.:..| ::|.        |...||...|:  
  Rat   869 SSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGP-RAGPCILPIVRDGRKVSSTHYYLLP 932

  Fly  1095 GSKGYRQRSTSF--------NESFHPISPVLSEPPQRERGVIQRQVR-LEQQQPLPRRSAS---- 1146
            ....|.:|...|        ..:..|:.|:|..|...........|| :.|..|.|:.:.|    
  Rat   933 ERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNS 997

  Fly  1147 ---YKPRSIRARTLRRLSYNPMTLDSSSSSGEEPVKPS------------LARSECDIRARVAAS 1196
               .:|.|:||..  ||...     .....|:|..:|:            :...||.     ||.
  Rat   998 NPGAQPPSLRASA--RLPQR-----GCPGDGQEAARPADKVQMLQAMVHGVTTEECQ-----AAL 1050

  Fly  1197 SNSSLGRRRRA---------GMNRQVQSACHDEREV 1223
            .:.|...:|.|         |:..:.:..||...|:
  Rat  1051 RSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVLEM 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938 26/62 (42%)
STYKc 133..396 CDD:214568 123/267 (46%)
PTKc_Ack_like 137..398 CDD:270636 124/265 (47%)
SH3 400..454 CDD:214620 15/54 (28%)
CRIB 486..525 CDD:238077 15/45 (33%)
Tnk2XP_038944232.1 SAM_TNK-like 38..99 CDD:188938 23/56 (41%)
PTKc_Ack_like 162..419 CDD:270636 124/265 (47%)
SH3_9 427..476 CDD:405311 15/51 (29%)
GTPase_binding 481..546 CDD:401099 19/85 (22%)
PHA03247 <649..1015 CDD:223021 85/495 (17%)
Inhibitor_Mig-6 851..907 CDD:402933 12/66 (18%)
UBA_ACK1 1030..1073 CDD:270460 8/47 (17%)
UBA_TNK1 1060..1099 CDD:270513 5/27 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0199
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D426644at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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