DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Tnk1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_006246766.1	Gene:	Tnk1 / 303247	RGDID:	1310113	Length:	740	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	213/730 - (29%)
Similarity:	322/730 - (44%)	Gaps:	134/730 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            |...|.:.:|.|:|..:..||.:|....|.:...|||..:|:.||..|||.:..::     |.|.
  Rat    83 LLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNLGMGRPAQRRLTEALKR-----YRSG 142

  Fly    73 IK------RLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPAD 131
            :|      ::|  .|...:::|.|          ..:.:...|....|..        |.:||..
  Rat   143 VKSKNWVYKIL--GGFAPEQKEIP----------PYSDSLPHLHEPEGGL--------KCLIPEG 187

  Fly   132 SISVNKQLGTGEFGIVQQGVWS-NGNERIQVAIKCLCRERM-QSNPM-----EFLKEAAIMHSIE 189
            ::...:.||:|.||:|.||:|: .|.:.|.||:|.|   |: ...||     :||:|.::|..:|
  Rat   188 AVCRGELLGSGCFGVVHQGLWTLPGGQSIPVAVKSL---RVGPEGPMGTELGDFLREVSVMMKLE 249

  Fly   190 HENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQK 254
            |.:::||:|:||. ..|.:|.|||.|.||...| .:...:..|.:..||.|..|:...|.||...
  Rat   250 HPHVLRLHGLVLG-QPLQMVMELAPLGSLHARL-TAPAPMPPLPVTLLCLFLRQLAGAMAYLGSC 312

  Fly   255 RLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            .|:|||||.||:|:.|..|:|::||||.|.||..:..|.  ......:|.||||||.:....|:.
  Rat   313 GLVHRDLATRNLLLASPRKIKVADFGLVRPLGGARGRYV--MGGPRPIPYAWCAPESLRQGAFSA 375

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            |||||.|||.||||||.|.:|||.:....||:.:: .:..||.:|..|....|:|.::||....|
  Rat   376 ASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLE-KDRARLPKPALCSRALYSLALRCWAPHPA 439

  Fly   385 KRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKT-- 447
            .||.|..:...|.:....:.:.|...|||  ..|....||.|::::.:..|..|||  ..|:|
  Rat   440 DRPTFSNLEGLLQEAWLSEGRCVREVTEP--GALRMEPGDPITIIEGSPDTTTWKG--QNGRTLK 500

  Fly   448 -GYFNPSN-TVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDG----A 506
             |.|..|. |:|.|.|.|.:          |.:.:        ..|....|:.|  |.||    |
  Rat   501 VGNFPASAVTLADLGGSPVT----------HPVHR--------GSPARGEKYRG--GTDGDREKA 545

  Fly   507 TFGDIAFLGSSQNYNH-VPKQIVTPYKPSEDIEQTPLLLPPTP----TSPDSLQTASGYFPEGAN 566
            ...|   |..::|... ||.|.:...  |:.:|.. |.|.|.|    :||..|:       .|..
  Rat   546 VLQD---LPPARNQRRKVPLQRMKGI--SKSLESV-LSLGPRPAGGGSSPPELR-------RGCT 597

  Fly   567 SGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNY--GADGK 629
            .....|.:..|...|.....|.:|.            |:.|..|:|...:.| .|||:  ||.|.
  Rat   598 RAWPQGLADLPPRPPDLPPRPPIIC------------SSQPIQPHRVRPKRE-PLHNHCTGAPGS 649

  Fly   630 S--------VHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATG 686
            |        ..|::.|:   |.||:.....|.::..|...           .:.:|.|.:::|.
  Rat   650 SKVTIPPGGPLSDSEWQ---RKIVEVELSVHGVTYQECQM-----------ALRTMGGDVASAI- 699

  Fly   687 SHPKSPGFDHVNNKN 701
            .:.|.....|::|::
  Rat   700 RNLKVDQLFHLSNRS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	18/56 (32%)
		STYKc	133..396	CDD:214568	106/269 (39%)
		PTKc_Ack_like	137..398	CDD:270636	107/267 (40%)
		SH3	400..454	CDD:214620	16/56 (29%)
		CRIB	486..525	CDD:238077	11/43 (26%)
Tnk1	XP_006246766.1	SAM_TNK-like	89..140	CDD:188938	16/55 (29%)
		STYKc	192..451	CDD:214568	106/266 (40%)
		PKc_like	193..453	CDD:304357	107/267 (40%)
		UBA_like_SF	668..711	CDD:304366	9/54 (17%)
		UBA_like_SF	698..737	CDD:304366	4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820