DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and jak2b

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_571162.1	Gene:	jak2b / 30298	ZFINID:	ZDB-GENE-980526-123	Length:	1126	Species:	Danio rerio

Alignment Length:	378	Identity:	124/378 - (32%)
Similarity:	184/378 - (48%)	Gaps:	67/378 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 YEKHFPHSYLSKIKRL--LQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPN 123
            ||..|..|:.:.|:.|  |..|...:.:|      |.:....::||..::...||  :.|.:. .
Zfish   775 YEPTFRPSFKAIIRDLNSLFCPDYEIVKE------SDIMPSRAAASIFNTGTFKN--NEPVQF-E 830

  Fly   124 NKHIIPADSISVNKQLGTGEFGIVQQGVWS--NGNERIQVAIKCLCRERMQSNPME----FLKEA 182
            .:|:|      ..:|||.|.||.|:...:.  ..|....||:|     ::|.:..|    |.:|.
Zfish   831 ERHLI------FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVK-----KLQHSTTEHIRDFEREI 884

  Fly   183 AIMHSIEHENIVRLYGVVLATD--SLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQIC 245
            .|:.|::|||||:..||.....  :|.||.|.....||.:.|..:..|:..   ..|..:|.|||
Zfish   885 EILKSLQHENIVKYKGVCYGAGRRNLRLVMEYLPYGSLRDYLNKNRDRIDH---QKLVHYASQIC 946

  Fly   246 NGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPE 310
            .||.||..||.||||||.|||||.|:.:|||.||||::.|...|:|||.  ....:.||.|.|||
Zfish   947 KGMEYLATKRYIHRDLATRNILVESECRVKIGDFGLTKVLPQDKEYYKV--KEPGESPIFWHAPE 1009

  Fly   311 CINYLRFTNASDVWAFGVCLWEMFSYGFQ------PWAALTG---------LQILEAIDAPNYQR 360
            .:...:|:.|||||:|||.|:|:|:|..:      .:.::.|         ..::|.:...|  |
Zfish  1010 SLTESKFSVASDVWSFGVVLYELFTYSDKLCSPPTVFLSMVGGDKQGQTIVYHLIELLKRGN--R 1072

  Fly   361 LEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI---------------YDQLPD 398
            |.||..||:|.:.:|.:||.:|.:.||.|.|:               |.|:|:
Zfish  1073 LPQPMGCPTEMFEIMQECWDNDPSLRPNFKELALRVDLIRDSSDADRYTQVPE 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	2/3 (67%)
		STYKc	133..396	CDD:214568	105/300 (35%)
		PTKc_Ack_like	137..398	CDD:270636	106/298 (36%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
jak2b	NP_571162.1	B41	29..262	CDD:214604
		FERM_B-lobe	144..253	CDD:271216
		FERM_C_JAK2	258..370	CDD:270141
		SH2_Jak2	370..466	CDD:198242
		PKc_like	528..791	CDD:304357	5/15 (33%)
		Pkinase_Tyr	528..790	CDD:285015	5/14 (36%)
		PKc_like	829..1112	CDD:304357	106/301 (35%)
		TyrKc	834..1104	CDD:197581	104/287 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910