DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Srms

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001011961.1	Gene:	Srms / 296472	RGDID:	1306602	Length:	507	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	119/401 - (29%)
Similarity:	190/401 - (47%)	Gaps:	80/401 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAPGT-MVKREEAPGGGSQVALDGSSA 103
            :|:...|.|:||.:.::|           .||.    ..|||. :::..|:..||..::: .:.|
  Rat   131 SDQPWYFNGISRTQAQQL-----------LLSP----ANAPGAFLIRPSESSIGGYSLSV-RAQA 179

  Fly   104 SAC---------SSLAAKNGASSPS------------KVPNNKHIIPA---------------DS 132
            ..|         ..|..:.|...||            |:..|..:.|.               ..
  Rat   180 KVCHYRICMAPSGGLYLQEGRLFPSLDALLAYYKTNWKLIQNPLLQPCVPQMPLAQDEWERPRSE 244

  Fly   133 ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLY 197
            ..:.::||.|.||.|.:|:|....   .||:|.:....|:.  .:..||...:.|:.||.::||:
  Rat   245 FVLRRKLGEGFFGEVWEGLWLGST---PVAVKVIKSADMKL--ADLTKEIEALKSLRHERLIRLH 304

  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRV-------SFLTIPTLCEFALQICNGMRYLEQKR 255
            .:....:.:.:||||         :....|:|       ..|::|.|..||.|:..||.|||::|
  Rat   305 AICSLGEPVYIVTEL---------MGKGNLQVYLGSPEGKALSLPHLLGFACQVAEGMSYLEERR 360

  Fly   256 LIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNA 320
            ::||||||||:||......|::||||:|.|  ..|.|..  :...|:|:.|.|||..||..|:..
  Rat   361 VVHRDLAARNVLVGDDLTCKVADFGLARLL--KDDVYSP--SSGSKIPVKWTAPEAANYRVFSQK 421

  Fly   321 SDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAK 385
            ||||:||:.|:|:|:||..|:..:|..:.|:.| :..| ||.:|..||:|.|.||::||:....:
  Rat   422 SDVWSFGILLYEVFTYGQCPYEGMTNHETLQQI-SRGY-RLPRPAVCPAEVYMLMVECWKGSPEE 484

  Fly   386 RPRFGEIYDQL 396
            ||.|..:.::|
  Rat   485 RPTFATLREKL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	6/24 (25%)
		STYKc	133..396	CDD:214568	95/269 (35%)
		PTKc_Ack_like	137..398	CDD:270636	96/267 (36%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Srms	NP_001011961.1	SH3	70..124	CDD:302595
		SH2	134..212	CDD:301589	19/93 (20%)
		PTKc_Srm_Brk	238..498	CDD:133248	96/278 (35%)
		Pkinase_Tyr	245..495	CDD:285015	95/269 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920